Delman David, Peng Xianming, Zedek Daniel C, Jewells Valerie, Chahin Nizar, Markovic-Plese Silva
Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA.
Department of Dermatology, 414 Mary Ellen Jones Building, Chapel Hill, NC 27599, USA.
J Neuroimmunol. 2015 Jan 15;278:108-11. doi: 10.1016/j.jneuroim.2014.07.016. Epub 2014 Jul 30.
This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM).
A 40year-old Caucasian female presented with 6months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate.
We recommend considering NMOSD in the differential diagnosis of patients with DM and other autoimmune disorders that also present with clinical signs of myelopathy.
这是首例关于视神经脊髓炎谱系障碍（NMOSD）与皮肌炎（DM）相关的报告。
一名40岁的白种女性，出现6个月来逐渐加重的疲劳、皮疹、下肢急性无力加重以及尿潴留。她被诊断为同时患有NMOSD和抗黑色素瘤分化相关基因（MDA）5阳性的皮肌炎，并伴有间质性肺病（ILD）。她接受了积极治疗，恢复了行走能力。
我们建议在对患有皮肌炎以及其他伴有脊髓病临床体征的自身免疫性疾病患者进行鉴别诊断时考虑NMOSD。
