Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, USA.
Department of Pediatrics, University of Washington School of Medicine, Seattle, USA.
Oncogene. 2018 Aug;37(35):4769-4780. doi: 10.1038/s41388-018-0304-2. Epub 2018 May 21.
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
E-钙黏蛋白是黏着连接的关键组成部分，对于细胞黏附和维持上皮细胞表型至关重要。细胞接触时，细胞间同种型 E-钙黏蛋白的结合对于接触抑制增殖非常重要，当细胞达到汇合时就会发生这种情况。E-钙黏蛋白表达的丧失导致接触抑制的丧失，并与细胞运动性增加和癌症的晚期阶段相关。在这篇综述中，我们讨论了 E-钙黏蛋白及其下游信号在调节接触抑制以及癌症的发生和进展中的作用。
