Laczi F, Vecsernyés M, Kovács G L, Penke B, Jójárt I, Janáky T, Telegdy G, László F A
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Exp Clin Endocrinol. 1988 Mar;92(3):328-34. doi: 10.1055/s-0029-1210822.
The effect of intracerebroventricular (i.c.v.) treatment of rat atrial natriuretic factor III (ANF III; 0.5 microgram) was measured on the arginine-8-vasopressin (AVP) and oxytocin (OXT) contents of rat hypothalamic and limbic brain areas as well as those in the plasma. The hormone concentrations were determined by radioimmunoassay (RIA). The administration of ANF III in conscious euhydrated rats resulted in a significant reduction of both AVP and OXT contents in the hippocampus. Ether anesthesia interfered with the effect of ANF III, since in anesthetized rats ANF III reduced the levels of AVP and OXT in the septal regions, too. ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl). The results suggest that ANF III may be important in the control of the activity of both the peripheral (hypothalamo-neurohypophyseal) and the central (brain) AVP-ergic and OXT-ergic systems.
通过向大鼠脑室内（i.c.v.）注射心房钠尿肽III（ANF III；0.5微克），检测其对大鼠下丘脑和边缘脑区以及血浆中精氨酸加压素8（AVP）和催产素（OXT）含量的影响。激素浓度通过放射免疫分析法（RIA）测定。向清醒的正常水合大鼠注射ANF III后，海马体中AVP和OXT的含量均显著降低。乙醚麻醉会干扰ANF III的作用，因为在麻醉大鼠中，ANF III也会降低隔区中AVP和OXT的水平。ANF III对基础血浆AVP和OXT浓度没有影响，然而，该肽可抑制高渗（腹腔注射2.5% NaCl）诱导的血浆AVP和OXT升高。结果表明，ANF III可能在控制外周（下丘脑-神经垂体）和中枢（脑）AVP能和OXT能系统的活性方面发挥重要作用。
