肠道相关淋巴组织反抑制性T细胞回路在同种型特异性免疫调节中的作用。
Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.
作者信息
Fujihashi K, Kiyono H, Beagley K W, Eldridge J H, McGhee J R
机构信息
Department of Microbiology, University of Alabama, Birmingham 35294.
出版信息
Adv Exp Med Biol. 1988;237:649-53. doi: 10.1007/978-1-4684-5535-9_98.
GALT contains Tcs cells which protect IgA responses under conditions of oral tolerance. Oral immunization of erythrocyte antigen induces antigen-specific Tcs cells in Peyer's patches which predominantly support IgA responses with minor IgM and IgG responses upon adoptive transfer to tolerized mice. On the other hand, systemically-primed mice possess Tcs cells which convert oral tolerance to only IgM and IgG responses. In general, effector Tcs cells which abrogate antigen-specific oral tolerance are Lyt-1+, Lyt-2-, L3T4-, I-J+ and V. villosa-adherent. Interestingly, these Tcs cells express T3 molecules which suggest the expression of a TCR which may account for their antigen specificity.
肠道相关淋巴组织（GALT）含有调节性T细胞（Tcs细胞），在口服耐受条件下保护IgA反应。红细胞抗原的口服免疫在派尔集合淋巴结中诱导抗原特异性Tcs细胞，这些细胞在过继转移到耐受小鼠后主要支持IgA反应，同时伴有少量IgM和IgG反应。另一方面，全身致敏的小鼠拥有将口服耐受转变为仅产生IgM和IgG反应的Tcs细胞。一般来说，消除抗原特异性口服耐受的效应性Tcs细胞是Lyt-1+、Lyt-2-、L3T4-、I-J+且黏附于绒毛膜。有趣的是，这些Tcs细胞表达T3分子，这表明可能存在一种TCR的表达，这或许可以解释它们的抗原特异性。
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