[Association of polymorphism 4a/4b and 4b/4b in endothelial nitric oxide synthase gene and markers of endothelial dysfunction in patients with chronic heart failure].

AIM

To examine the association of polymorphism 4a/4b and 4b/4b in endothelial nitric oxide synthase gene (eNOS) with levels of natriuretic peptide type-C, endothelin-1 and vasoregulative endothelial function in patients with chronic heart failure (CHF) depending on the ejection fraction of the left ventricle.

MATERIALS AND METHODS

The study has included 280 patients with CHF of ischemic etiology and 60 somatically healthy individuals. A comprehensive assessment of the markers of the vascular endothelium function was carried out for all patients (endothelial function coefficient, natriuretic peptide type-C, endothelin-1) in association of polymorphism 4a/4b and 4b/4b gene of eNOS.

RESULTS

Correlations between the ejection fraction of the left ventricle and the levels of the natriuretic peptide-type C and endothelin-1 have been established. Endothelial dysfunction was revealed in all patients with CHF, but patients with 4a/4b gene of eNOS had more pronounced disorders. The association between the levels of biochemical markers of the endothelial dysfunction with polymorphism 4a/4b gene eNOS was also rervealed. The levels of the natriuretic peptide type C and endothelin-1 were higher in subgroups with genotype 4a/4b of gene eNOS both in patients with CHF with a preserved and with a reduced ejection fraction of the left ventricle.

CONCLUSION

In patients with CHF with preserved and reduced ejection fraction of the left ventricle the association of polymorphism 4a/4b gene eNOS with levels of biochemical markers of endothelial dysfunction and vasoregulative endothelial function was revealed.