Vicariot M, Charpentier M C, Colin F, Le Roux A M
Unité d'Hémobiologie-Transfusion, CHR, Brest.
Presse Med. 1988 Oct 15;17(35):1789-92.
The sera from 38 patients with suspected drug-induced thrombocytopenia (22) or neutropenia (16) were tested with the indirect immunofluorescence test on platelets or granulocytes for the presence of drug-dependent antibodies. Three drug-induced antibodies with reactivity against platelets and 5 with reactivity against granulocytes were detected. In 3 sera antibodies were found which reacted already with target cells without adding the drug to the test system. These data show that drug-induced blood dyscrasias often have an immunological cause and that in vitro tests can be helpful in detecting the responsible drug. Different mechanisms can be involved. In many sera circulating antibodies were not found, but an immunological mechanism is likely to be involved in some of these cytopenias: the antibody could be entirely absorbed by the target cells, a metabolite of the drug could be the immunogen and finally the test may not be sensitive enough.
对38例疑似药物性血小板减少症（22例）或中性粒细胞减少症（16例）患者的血清进行检测，采用间接免疫荧光法检测血小板或粒细胞上是否存在药物依赖性抗体。检测到3种与血小板反应的药物诱导抗体和5种与粒细胞反应的药物诱导抗体。在3份血清中发现抗体，即使在检测系统中不添加药物，这些抗体也已经与靶细胞发生反应。这些数据表明，药物性血细胞减少症往往有免疫原因，体外检测有助于发现致病药物。可能涉及不同机制。在许多血清中未发现循环抗体，但这些血细胞减少症中的一些可能涉及免疫机制：抗体可能完全被靶细胞吸收，药物的代谢产物可能是免疫原，最后检测可能不够敏感。
