Finegold Peter, Mathieson Kate, Holmes Leah, Boon Martin, Cottle Mark, Donnai Dian, Middleton-Price Helen
The Nowgen Centre, Nowgen, A Centre for Genetics in Healthcare, 29 Grafton St, Manchester, M13 9WU, UK.
The University of Manchester, Manchester, UK.
Per Med. 2008 Jan;5(1):65-76. doi: 10.2217/17410541.5.1.65.
While discussion about the potential for personalized medicine persists, in the UK embedding pharmacogenetics in mainstream clinical practice will also depend on high levels of confidence and trust of citizens in the motives of stakeholders. The role of Government, regulators and the guidance offered by health practitioners will contribute to its acceptance or otherwise. Nowgen, a center for genetics in healthcare, is dedicated to exploring how health service research, practice and innovation, in relation to genetic medicine, are informed and perceived by the public. In 2006, Nowgen commissioned a national polling organization, ICM, to carry out a representative survey of UK public attitudes to key questions related to genetic medicine, in order to help inform its future activity. The survey indicated that the UK public is relatively well informed about the contribution made by genes to common and complex disease and that it is fairly optimistic about the role of genetics in the treatment of a range of medical conditions. A significant proportion of the population seem reticent to subscribe to genetic testing in order to personalize drug prescription, although the rationale for resistance is, as yet, unclear.
尽管关于个性化医疗潜力的讨论仍在继续，但在英国，将药物遗传学融入主流临床实践还将取决于公民对利益相关者动机的高度信心和信任。政府、监管机构的作用以及医疗从业者提供的指导将有助于其被接受与否。Nowgen是一个医疗保健遗传学中心，致力于探索公众如何看待和了解与基因医学相关的卫生服务研究、实践和创新。2006年，Nowgen委托一家全国性民意调查机构ICM对英国公众对与基因医学相关关键问题的态度进行代表性调查，以指导其未来活动。调查表明，英国公众对基因在常见和复杂疾病中的作用了解相对较多，并且对遗传学在一系列医疗状况治疗中的作用相当乐观。尽管抵制的理由尚不清楚，但很大一部分人似乎不愿接受基因检测以实现药物处方个性化。
