?>Department of Ophthalmology, Jewish General Hospital, McGill University, Montreal, Que; University of Manitoba, Winnipeg, Man.
Royal Victoria Hospital, Montreal, Que.
Can J Ophthalmol. 2018 Jun;53(3):242-245. doi: 10.1016/j.jcjo.2017.10.029. Epub 2018 Feb 1.
To study the prevalence of the systemic use of some common classes of medications by glaucoma patients and their relationship to the prevalence and severity of chronic open-angle glaucoma (COAG) and primary-angle closure glaucoma (PACG).
Observational prospective single-centre cross-sectional study.
Glaucoma patients or their pharmacist provided an updated list of all systemic medications that they presently use. The relationship between glaucoma type and severity and medication use for diseases other than glaucoma was assessed by univariate statistics.
We studied 514 glaucoma patients. They use a mean of 4.9 oral medications prescribed by a mean of 2.1 doctors. Antihypertensives, medications with anticholinergic properties, steroids, anticoagulants, and thyroid hormones were the most frequently prescribed groups of medications, used by 251 (49%), 178 (35%), 100 (19%), 218 (42%), and 108 (21%) patients, respectively. Steroid usage was associated with advanced visual field loss in COAG patients. Antihypertensives and medications with anticholinergic properties were not associated with severity of COAG and PACG, respectively, and these 3 groups were not associated with an increased prevalence of diagnosis of COAG or PACG.
Glaucoma patients take many systemic medications in addition to their topical glaucoma treatment.
研究青光眼患者全身使用某些常见类别的药物的流行情况及其与慢性开角型青光眼（COAG）和原发性闭角型青光眼（PACG）的流行和严重程度的关系。
观察性前瞻性单中心横断面研究。
青光眼患者或其药剂师提供了他们目前正在使用的所有全身药物的最新清单。通过单变量统计评估了青光眼类型和严重程度与治疗青光眼以外疾病的药物使用之间的关系。
我们研究了 514 名青光眼患者。他们平均使用 4.9 种口服药物，平均由 2.1 位医生开具。抗高血压药、具有抗胆碱能特性的药物、类固醇、抗凝剂和甲状腺激素是最常开的药物组，分别有 251 名（49%）、178 名（35%）、100 名（19%）、218 名（42%）和 108 名（21%）患者使用。类固醇的使用与 COAG 患者的视野进行性丧失有关。抗高血压药和具有抗胆碱能特性的药物与 COAG 和 PACG 的严重程度分别无关，这 3 组与 COAG 或 PACG 的诊断率增加无关。
除了局部治疗青光眼外，青光眼患者还会服用许多全身性药物。
