Wakefield Denis, Wildner Gerhild
School of Medical Science UNSW and NSWHP Sydney NSW Australia.
Section of Immunobiology Augenklinik und Poliklinik LMU Klinikum München Germany.
Clin Transl Immunology. 2020 Oct 6;9(10):e1180. doi: 10.1002/cti2.1180. eCollection 2020.
There is increasing evidence from animal and human studies that glaucoma is an autoimmune disease. Evidence for this hypothesis includes the fact that antibodies as well as T-cell responses to heat-shock proteins (HSPs) are detectable in some patients with glaucoma and in an animal model of the disease. As in the human disease, experimental animal models of glaucoma have been found to demonstrate neurodegenerative changes in the optic nerve associated with immunoglobulin and T-cell infiltration. Although there is still insufficient evidence in humans to classify all cases of glaucoma as autoimmune diseases, the implications of this hypothesis have major impact on the diagnosis and treatment of glaucoma.
来自动物和人体研究的证据越来越多，表明青光眼是一种自身免疫性疾病。这一假说的证据包括，在一些青光眼患者以及该疾病的动物模型中可检测到针对热休克蛋白（HSPs）的抗体以及T细胞反应。与人类疾病一样，已发现青光眼的实验动物模型表现出与免疫球蛋白和T细胞浸润相关的视神经神经退行性变化。尽管在人类中仍没有足够的证据将所有青光眼病例归类为自身免疫性疾病，但这一假说的影响对青光眼的诊断和治疗具有重大意义。
