National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Vaccine. 2018 Dec 14;36(51):7894-7900. doi: 10.1016/j.vaccine.2018.05.008. Epub 2018 May 18.
A prospective, multicentre study was conducted in four sentinel surveillance hospitals to assess the trend and epidemiology of acute diarrhea caused by Rotavirus in Vietnam. During the period 2012-2015, a total 8,889 children under 5 years of age were enrolled in the surveillance, and 8689 stool samples were collected. Of these cases, Rotavirus was most common pathogen 46.7% (4054 cases); in which 26.6% (1117) rotavirus-positive stool samples were evaluated to identify genotypes. The proportion of rotavirus positive specimens decreased annually from 54.7% in 2012 to 36.6% in 2015. Rotavirus was detected year-round, but most rotavirus gastroenteritis cases (77.1%) occurred between December and May, corresponding to the rotavirus seasonality. It is found that the peaks varied by regions. Rotavirus positivities varied between the youngest and oldest age, but children 6-11 months old (38.8%) and 12-23 months old (38.4%) counted for most cases. A significant higher number of diarrhea within 24 hours (8.3 times, 95%CI: 8.1-8.4 times) and higher proportion of severe dehydration (12.9%) in Rotavirus positive group than that in Rotavirus negative group (7.7 times, 95%CI: 7.6-7.9 times; and 9.7%, respectively). A downtrend of prevalence of G1P[8] was observed from 82% in 2013 to 15% in 2015. However, G2P[4] was found in 5% of samples in 2012, 9% in 2013, 36% in 2014, and 28% in 2015. Rotavirus infection is the most important cause of acute diarrhea among hospitalized children in Vietnam, and a rotavirus vaccination program for children may significantly reduce this disease.
一项前瞻性、多中心研究在越南四家哨点监测医院进行，以评估轮状病毒引起的急性腹泻的趋势和流行病学。2012 年至 2015 年期间，共纳入 8889 名 5 岁以下儿童进行监测，采集了 8689 份粪便样本。在这些病例中，轮状病毒是最常见的病原体，占 46.7%（4054 例）；其中 26.6%（1117 例）的轮状病毒阳性粪便样本用于鉴定基因型。轮状病毒阳性标本的比例逐年下降，从 2012 年的 54.7%降至 2015 年的 36.6%。轮状病毒全年均可检测到，但大多数轮状病毒胃肠炎病例（77.1%）发生在 12 月至 5 月，与轮状病毒季节性相对应。发现不同地区的高峰有所不同。轮状病毒阳性率在年龄最小和最大的儿童之间存在差异，但 6-11 个月（38.8%）和 12-23 个月（38.4%）的儿童占大多数病例。轮状病毒阳性组腹泻在 24 小时内的发生率（8.3 倍，95%CI：8.1-8.4 倍）和严重脱水的比例（12.9%）显著高于轮状病毒阴性组（7.7 倍，95%CI：7.6-7.9 倍；9.7%）。2013 年 G1P[8]的流行率从 82%下降到 2015 年的 15%，而 G2P[4]在 2012 年为 5%，2013 年为 9%，2014 年为 36%，2015 年为 28%。轮状病毒感染是越南住院儿童急性腹泻的最重要原因，为儿童接种轮状病毒疫苗可能会显著降低该病的发病率。
