不可切除的默克尔细胞癌的放射治疗：一项系统评价和汇总分析。
Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis.
作者信息
Patel Parth, Modi Chirag, McLellan Beth, Ohri Nitin
机构信息
Department of Medicine, Division of Dermatology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
出版信息
Dermatol Pract Concept. 2018 Apr 30;8(2):149-157. doi: 10.5826/dpc.0802a15. eCollection 2018 Apr.
BACKGROUND
Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking.
OBJECTIVE
We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC.
METHODS
We performed a systematic review of the current literature. Articles published in English in the PubMed database up to July 29, 2016, were evaluated.
RESULTS
Eight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis. Of the 24 stage I/II patients treated with local irradiation, 6 (25%) relapsed and 1 (4%) died from MCC. Of the 24 stage I/II patients treated with local and regional nodal irradiation, 5 (21%) relapsed and 2 (8%) died from MCC. Of the 20 stage III patients treated with local and regional nodal irradiation, 12 (60%) relapsed and 7 (35%) died from MCC.
CONCLUSIONS
Radiation monotherapy appears to be a reasonable treatment modality for patients with inoperable stage I-III MCC. Further investigation with prospective studies is needed to draw definitive conclusions.
背景
缺乏关于默克尔细胞癌（MCC）放射单药治疗的累积数据。
目的
我们试图综合所有关于无法手术的I - III期MCC放射单药治疗结局的可用数据。
方法
我们对当前文献进行了系统评价。评估了截至2016年7月29日在PubMed数据库中以英文发表的文章。
结果
我们的分析纳入了8篇病例报告、4个病例系列和6项回顾性研究，共68例患者。在24例接受局部照射的I/II期患者中，6例（25%）复发，1例（4%）死于MCC。在24例接受局部和区域淋巴结照射的I/II期患者中，5例（21%）复发，2例（8%）死于MCC。在20例接受局部和区域淋巴结照射的III期患者中，12例（60%）复发，7例（35%）死于MCC。
结论
放射单药治疗似乎是无法手术的I - III期MCC患者的一种合理治疗方式。需要进行前瞻性研究以得出明确结论。
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