使用 TMPMgCl·LiCl 对溴芴醛进行区域选择性邻位官能化。
Regioselective ortho-functionalization of bromofluorenecarbaldehydes using TMPMgCl·LiCl.
机构信息
University of Bremen, Department of Organic and Analytical Chemistry, Leobener Straße 7, 28359 Bremen, Germany.
出版信息
Org Biomol Chem. 2018 Jun 6;16(22):4071-4075. doi: 10.1039/c8ob01072b.
PMID:29785418
Abstract
A highly regioselective functionalization of 7-bromofluorene-2-carbaldehydes, potent organic chromophores, in position C3 using a mild ortho-metallation strategy (DoM) with TMPMgCl·LiCl has been developed. This approach allows the preparation of highly functionalized fluorene derivatives by conversion of the in situ generated metalated species with various electrophiles giving a fast access to novel organic phosphorescent dyes.
摘要
开发了一种使用温和的邻位金属化策略（DoM）与 TMPMgCl·LiCl 在 7-溴芴-2-醛（强有机生色团）的 C3 位进行高区域选择性官能化的方法。该方法通过将原位生成的金属化物种与各种亲电试剂转化，可制备高度官能化的芴衍生物，从而快速获得新型有机磷光染料。
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