Ihm C G, Woo J T, Chang Y W, Kwon O S, Kim M J
Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
J Korean Med Sci. 1986 Sep;1(1):43-8. doi: 10.3346/jkms.1986.1.1.43.
T cell immunity and phagocytic activity were studied in the blood of patients with IgA nephropathy in order to clarify their roles in the pathogenesis of IgA nephropathy. The percentages of total T lymphocytes, helper T cell and suppressor T cells were significantly reduced in patients. A significantly elevated helper T cell/suppressor T cell ratio in patients showed a predominant reduction in suppressor T cells. There was a significant relationship between histologic findings and helper T cell/suppressor T cell ratio in patients. Natural Killer (NK) cell activity was significantly reduced but the lymphocyte response after phytohemagglutinin (PHA) stimulation was not in patients. ConA-induced suppressor cell activity was not depressed despite of a decrease in suppressor T cells in patients. Phagocytic activity of polymorphonuclear leucocytes (PMNs) ingesting yeasts was significantly reduced in patients. Also an inverse correlation was found between serum IgA levels and phagocytic activity of PMN. It is concluded that suppressor T cell defects, depressed phagocytic activity and impaired NK cell activity may play a role in the pathogenesis of IgA nephropathy.
为了阐明T细胞免疫和吞噬活性在IgA肾病发病机制中的作用，对IgA肾病患者的血液进行了研究。患者的总T淋巴细胞、辅助性T细胞和抑制性T细胞百分比显著降低。患者辅助性T细胞/抑制性T细胞比值显著升高，表明抑制性T细胞明显减少。患者的组织学表现与辅助性T细胞/抑制性T细胞比值之间存在显著关系。患者的自然杀伤（NK）细胞活性显著降低，但植物血凝素（PHA）刺激后的淋巴细胞反应未受影响。尽管患者抑制性T细胞减少，但刀豆蛋白A诱导的抑制细胞活性并未降低。患者摄入酵母的多形核白细胞（PMN）的吞噬活性显著降低。此外，血清IgA水平与PMN的吞噬活性之间存在负相关。结论是，抑制性T细胞缺陷、吞噬活性降低和NK细胞活性受损可能在IgA肾病的发病机制中起作用。
