Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Nutrition and Clinical Services Division, 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212, Bangladesh.
Environ Microbiol. 2018 Jun;20(6):2256-2269. doi: 10.1111/1462-2920.14274. Epub 2018 Aug 7.
We report streptococcal dysbiosis in acute diarrhoea irrespective of aetiology. Compared with 20 healthy local controls, 71 Bangladeshi children hospitalized with acute diarrhoea (AD) of viral, mixed viral/bacterial, bacterial and unknown aetiology showed a significantly decreased bacterial diversity with loss of pathways characteristic for the healthy distal colon microbiome (mannan degradation, methylerythritol phosphate and thiamin biosynthesis), an increased proportion of faecal streptococci belonging to the Streptococcus bovis and Streptococcus salivarius species complexes, and an increased level of E. coli-associated virulence genes. No enteropathogens could be attributed to a subgroup of patients. Elevated lytic coliphage DNA was detected in 2 out of 5 investigated enteroaggregative E. coli (EAEC)-infected patients. Streptococcal outgrowth in AD is discussed as a potential nutrient-driven consequence of glucose provided with oral rehydration solution.
我们报告了急性腹泻中的链球菌失调，无论病因如何。与 20 名健康的当地对照相比，71 名因急性腹泻（AD）住院的孟加拉国儿童（病因包括病毒、混合病毒/细菌、细菌和未知原因）的细菌多样性明显降低，失去了健康远端结肠微生物组的特征途径（甘露聚糖降解、甲基赤藓醇磷酸和硫胺素生物合成），粪便链球菌中属于牛链球菌和唾液链球菌种复合体的比例增加，与大肠杆菌相关的毒力基因水平增加。没有一种肠道病原体可以归因于一组患者。在 5 名调查的聚集性大肠埃希菌（EAEC）感染患者中的 2 名患者中检测到了升高的裂解性大肠噬菌体 DNA。急性腹泻中链球菌的过度生长被认为是口服补液溶液提供的葡萄糖引起的潜在营养驱动的结果。
