Biomedical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Microbiology and Immunology Research Program, Children's Cancer Hospital Egypt 57357, Cairo, Egypt.
Gut Microbes. 2023 Dec;15(2):2249152. doi: 10.1080/19490976.2023.2249152.
is an abundant member of the human gastrointestinal microbiome, whose relative abundance has curiously been associated with positive and negative impacts on diseases, such as Parkinson's disease and rheumatoid arthritis. Yet, the verdict is still out on the definitive role of in human health, and on the effect of different diets on its relative abundance in the gut microbiome. The puzzling discrepancies among studies have only recently been attributed to the diversity of its strains, which substantially differ in their encoded metabolic patterns from the commonly used reference strain. However, such strain differences cannot be resolved by common 16S rRNA amplicon profiling methods. Here, we scrutinize , its versatile metabolic potential, and the hypotheses behind the conflicting observations on its association with diet and human health. We also provide suggestions for designing studies and bioinformatics pipelines to better research .
是人类胃肠道微生物组中丰富的一员，其相对丰度与帕金森病和类风湿性关节炎等疾病的积极和消极影响有关，这令人感到好奇。然而，关于在人类健康中的明确作用，以及不同饮食对其在肠道微生物组中相对丰度的影响，仍未有定论。最近才发现，之所以在研究中存在令人困惑的差异，是因为其菌株的多样性，与常用的参考菌株相比，其编码的代谢模式有很大的不同。然而，常见的 16S rRNA 扩增子分析方法无法解决这些菌株差异。在这里，我们仔细研究了它的多功能代谢潜力，以及关于它与饮食和人类健康关联的矛盾观察背后的假设。我们还为设计研究和生物信息学管道提供了建议，以更好地研究 。
