液体伤口敷料在慢性溃疡伤口治疗中的临床应用

[CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS].

作者信息

Wang Chen, Li Ting, Luo Pengfei, Liu Yingying, Wu Guosheng, Cheng Dasheng, Ben Daofeng, Xia Zhaofan

机构信息

Department of Burn and Trauma Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China.

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Dec 8;30(12):1507-1511. doi: 10.7507/1002-1892.20160312.

DOI:10.7507/1002-1892.20160312

PMID:29786343

Abstract

OBJECTIVE

To evaluate the effectiveness of liquid wound dressing in the treatment of chronic ulcer wounds.

METHODS

Between January 2014 and October 2015, 84 patients with chronic ulcer wounds were included and divided into 2 groups randomly. The chronic ulcer wounds were covered with liquid wound dressing in the treatment group (=44) and were managed with iodophor in the control group (=40). There was no significant difference in age, gender, causes, location, wound area, and disease duration between 2 groups (>0.05). The frequency of dress changing, effective rate of treatment, wound healing time, wound healing rate at 5, 10, and 20 days, positive rate of bacteria culture at 1, 5, and 10 days, and the rate of side effect were recorded and compared between 2 groups. Vancouver scar scale was used to evaluate scar formation.

RESULTS

The effective rate of the treatment group (100%) was significantly higher than that of the control group (85%) (=0.009). The frequency of dress changing in the treatment group[(11.36±3.40) times] was significantly lower than that in the control group[(16.94±4.51) times] (=-6.231, =0.000). The wound healing rates at 5, 10, and 20 days were significantly increased (<0.05) and the wound healing time was significantly decreased (=-6.627, =0.000) in the treatment group when compared with the control group. The positive rates of bacteria culture at 5 and 10 days in the treatment group were significantly lower than those in the control group (=12.313, =0.000; =0.005), but no significant difference was found at 1 day (=0.066, =0.797). Side effect was observed in 4 cases of the control group. Vancouver scar scale score was 8.59±1.32 in the treatment group and was 9.85±1.65 in the control group, showing significant difference (=-3.752, =0.000).

CONCLUSIONS

The application of the liquid wound dressing in the treatment of chronic ulcer wound can improve the wound healing rate, shorten the healing time and decrease the frequency of dress change, which could promote the wound healing process.

摘要

目的

评估液体伤口敷料治疗慢性溃疡伤口的有效性。

方法

2014年1月至2015年10月，纳入84例慢性溃疡伤口患者并随机分为2组。治疗组（n = 44）用液体伤口敷料覆盖慢性溃疡伤口，对照组（n = 40）用碘伏处理。两组在年龄、性别、病因、部位、伤口面积和病程方面无显著差异（P>0.05）。记录并比较两组的换药频率、治疗有效率、伤口愈合时间、5天、10天和20天的伤口愈合率、1天、5天和10天的细菌培养阳性率以及副作用发生率。采用温哥华瘢痕量表评估瘢痕形成情况。

结果

治疗组的有效率（100%）显著高于对照组（85%）（P = 0.009）。治疗组的换药频率[（11.36±3.40）次]显著低于对照组[（16.94±4.51）次]（t = -6.231，P = 0.000）。与对照组相比，治疗组5天、10天和20天的伤口愈合率显著提高（P<0.05），伤口愈合时间显著缩短（t = -6.627，P = 0.000）。治疗组5天和10天的细菌培养阳性率显著低于对照组（P = 12.313，P = 0.000；P = 0.005），但1天时无显著差异（P = 0.066，P = 0.797）。对照组有4例出现副作用。治疗组温哥华瘢痕量表评分为8.59±1.32，对照组为9.85±1.65，差异有统计学意义（t = -3.752，P = 0.