[骨关节炎中软骨内成骨的病理学研究进展]
[RESEARCH PROGRESS OF PATHOLOGY OF ENDOCHONDRAL OSSIFICATION IN OSTEOARTHRITIS].
作者信息
Xiao Zhifeng, Lin Dingkun
机构信息
The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou Guangdong, 510120, P. R. China.
Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou Guangdong, 510120, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Dec 8;30(12):1556-1561. doi: 10.7507/1002-1892.20160320.
OBJECTIVE
To summarize the research progress of pathological manifestations and mechanism of endochondral ossification in osteoarthritis (OA).
METHODS
The literature about endochondral ossification, bone-cartilage remodeling in OA, and joints development was reviewed, analyzed, and summarized.
RESULTS
Chondrocyte hypertrophy and apoptosis, vascular invasion, replication of the tidemark, thickening calcified cartilage, and thinning superficial cartilage are the characteristics of cartilage degeneration in OA. Articular cartilage and growth plate are similar in structure, and cartilage degeneration in OA is similar to a process of endochondral ossification of the growth plate.
CONCLUSIONS
Loss of stability characterization from resting metabolic balance to a high conversion state of temporary cartilage in stimulation of abnormal mechanical stresses and cytokines would subsequently contributed to continual calcification and remodeling of articular cartilage, which may be the key link of the initiation and development of OA.
目的
总结骨关节炎（OA）中软骨内成骨的病理表现及机制的研究进展。
方法
回顾、分析并总结有关软骨内成骨、OA中骨 - 软骨重塑及关节发育的文献。
结果
软骨细胞肥大与凋亡、血管侵入、潮线复制、钙化软骨增厚及表层软骨变薄是OA中软骨退变的特征。关节软骨与生长板结构相似，OA中的软骨退变类似于生长板的软骨内成骨过程。
结论
在异常机械应力和细胞因子刺激下，从静止代谢平衡到临时软骨高转化状态的稳定性特征丧失，随后会导致关节软骨持续钙化和重塑，这可能是OA发生和发展的关键环节。
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