Techna Institute for the Advancement of Technology for Health, University Health Network, 100 College Street, Toronto, ON M5G 1P5, Canada.
Analyst. 2018 Jun 11;143(12):2717-2722. doi: 10.1039/c8an00310f.
Ambient Mass Spectrometry (MS) analysis is widely used to characterize biological and non-biological samples. Advancements that allow rapid analysis of samples by ambient methods such as Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and Rapid Evaporative Ionization Mass Spectrometry (REIMS) are discussed. A short, non-comprehensive overview of ambient MS is provided that only contains example applications due to space limitations. A spatially encoded mass spectrometry analysis concept to plan cancer resection is introduced. The application of minimally destructive tissue ablation probes to survey the surgical field for sites of pathology using on-line analysis methods is discussed. The technological challenges that must be overcome for ambient MS to become a robust method for intrasurgical pathology assessments are reviewed.
环境质谱分析（MS）广泛用于生物和非生物样本的特征分析。本文讨论了允许通过环境方法（如解吸电喷雾电离质谱（DESI-MS）和快速蒸发离子化质谱（REIMS））快速分析样本的进展。由于篇幅限制，本文仅提供了一个简短的、非全面的环境 MS 概述，其中包含了示例应用。本文提出了一种基于空间编码的质谱分析概念，用于规划癌症切除术。本文还讨论了使用在线分析方法，通过最小侵入性组织消融探针探测手术区域的病理部位，以进行手术现场评估。本文回顾了环境 MS 成为术中病理评估的可靠方法所必须克服的技术挑战。
