School of Physical Sciences, Ingram Building, University of Kent, Canterbury, CT2 7NH, UK.
Macromol Rapid Commun. 2018 Jul;39(14):e1800182. doi: 10.1002/marc.201800182. Epub 2018 May 22.
As more evidence emerges supporting the possibility that nonsteroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management of certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumors. The primary disadvantage so far has been in use of nontherapeutic polymeric backbones that constitute the majority of the therapeutic particle's size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. This work demonstrates the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through the formation of nanostructures.
随着越来越多的证据支持非甾体抗炎药（尤其是阿司匹林）在预防和治疗某些类型癌症方面可能具有作用，人们已经尝试制造基于水杨酸的聚合物，这些聚合物可用于肿瘤的靶向治疗。迄今为止，主要的缺点是使用非治疗性聚合物骨架，这些骨架构成了治疗颗粒大小的大部分。本研究的重点是制造仅由水杨酸组成的可生物降解聚合物，并将其用作靶向纳米治疗的主要构建块，从而提供高局部剂量和活性部分的持续释放。这项工作展示了聚水杨酸盐的合成和降解，以及通过形成纳米结构来调节其尺寸和水解稳定性。
