College of Biology , Hunan University , Changsha 410082 , China.
ACS Appl Mater Interfaces. 2018 Jun 20;10(24):20334-20341. doi: 10.1021/acsami.8b04946. Epub 2018 Jun 11.
One of the main drawbacks that limits the application of mineral trioxide aggregate (MTA) in dental field is its long setting time. Mineral trioxide aggregate with accelerated setting properties and excellent chemical-physical and biological properties is still required. In this study, an innovative mineral trioxide aggregate, which consists of calcium silicates, calcium aluminates, and zirconium oxide, was designed to obtain fast-setting property. The optimized formulation can achieve initial setting in 10 min and final setting in 15 min, which are much faster than commercial mineral trioxide aggregate. In addition, the optimized fast-setting MTA showed adequate radiopacity and good biocompatibility. The ion concentrations after storage in water for 1 day were 52.3 mg/L Ca, 67.7 mg/L Al, 48.8 mg/L Si, and 11.7 mg/L Mg. The hydration products of hardened cements were investigated by X-ray diffraction, scanning electron microscopy, and Fourier transform infrared, showing the accelerated setting time was due to the formation of honeycomb-like calcium silicate hydrate gel. The novel MTA could be a promising material for dental applications.
矿化三氧化物凝聚体（MTA）在牙科领域的应用受到其凝固时间长的限制。因此，仍需要具有加速凝固性能和优异的理化及生物学性能的矿化三氧化物凝聚体。本研究设计了一种新型的矿化三氧化物凝聚体，由硅酸钙、铝酸钙和氧化锆组成，以获得快速凝固性能。优化后的配方可在 10 分钟内达到初始凝固，15 分钟内达到最终凝固，明显快于商用矿化三氧化物凝聚体。此外，优化后的快速凝固 MTA 具有足够的射线不透性和良好的生物相容性。在水中储存 1 天后，离子浓度分别为 52.3 mg/L Ca、67.7 mg/L Al、48.8 mg/L Si 和 11.7 mg/L Mg。通过 X 射线衍射、扫描电子显微镜和傅里叶变换红外光谱研究了硬化水泥的水化产物，表明加速凝固时间是由于形成了蜂窝状硅酸钙水凝胶。新型 MTA 可能是一种有前途的牙科应用材料。
