CCNU-uOttawa Joint Research Centre, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry , Central China Normal University , 152 Luoyu Road , Wuhan , Hubei 430079 , China.
State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry , 345 Lingling Road , Shanghai 200032 , China.
Org Lett. 2018 Jun 1;20(11):3314-3318. doi: 10.1021/acs.orglett.8b01208. Epub 2018 May 22.
The first example of a Pd(OAc)-catalyzed ring-forming alkene aminoaroylation of unsaturated hydrazones and sulfonamides is described. This protocol features the use of diaryliodonium salts as both oxidants and aryl sources, thus enabling mild reaction conditions, good chemoselectivity, a broad substrate scope, and high functional group tolerance. A wide range of synthetically and biologically important functionalized dihydropyrazoles and isoxazolidines have been obtained in good yields.
本文首次描述了 Pd(OAc)催化的不饱和腙和磺酰胺的环形成烯基氨基芳酰化反应。该方案的特点是使用二芳基碘鎓盐作为氧化剂和芳基源，从而实现了温和的反应条件、良好的化学选择性、广泛的底物范围和高官能团耐受性。通过该方法可以以良好的收率获得多种具有合成和生物重要性的官能化二氢吡唑和异噁唑啉。
