自发性高血压患者红细胞离子钙浓度：钙拮抗剂PN 200.110对其体内的调节作用

Red blood cell ionized calcium concentration in spontaneous hypertension: modulation in vivo by the calcium antagonist PN 200.110.

Morris M J, David-Dufilho M, Devynck M A

INSERM U7, Hôpital Necker, Paris, France.

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):257-60. doi: 10.1111/j.1440-1681.1988.tb01068.x.

Abstract

Altered calcium regulation has been observed in experimental and human hypertension. In this study erythrocyte (RBC) intracellular calcium concentration ([Ca2+]i) was compared in conscious spontaneously hypertensive rats (SHR) and their normotensive controls (WKY) at rest and after injection of the dihydropyridine calcium antagonist PN 200.110. 2. Resting [Ca2+]i was similar in SHR and WKY. 3. PN 200.110 administration induced a rapid decrease in blood pressure in SHR and WKY. Five minutes after the injection no change in [Ca2+]i was observed; at 1 h [Ca2+]i was significantly decreased in SHR, but not in WKY. 4. These results suggest that the mutual adaptation of the rate of calcium influx through calcium channels and the activity of the calcium extruding pump differ between WKY and SHR.

摘要

在实验性高血压和人类高血压中均观察到钙调节改变。在本研究中，比较了清醒自发性高血压大鼠（SHR）及其正常血压对照（WKY）在静息状态下以及注射二氢吡啶类钙拮抗剂PN 200.110后的红细胞（RBC）细胞内钙浓度（[Ca2+]i）。2. SHR和WKY的静息[Ca2+]i相似。3. 给予PN 200.110可使SHR和WKY的血压迅速下降。注射后5分钟，未观察到[Ca2+]i的变化；1小时时，SHR的[Ca2+]i显著降低，而WKY未降低。4. 这些结果表明，WKY和SHR之间通过钙通道的钙内流速率与钙泵出活性的相互适应性存在差异。