容量扩张和收缩对人体血浆心房利钠肽水平的影响。

Effects of volume expansion and contraction on plasma levels of atrial natriuretic peptide in man.

Finn W L, Gordon R D, Tunny T J, Klemm S A, Hamlet S M

University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):311-5. doi: 10.1111/j.1440-1681.1988.tb01079.x.

Abstract

Effects of saline infusion and blood removal on atrial natriuretic peptide (ANP) in normal subjects were examined in order to better define the magnitude of acute central volume regulatory influences on ANP. 2. Plasma ANP levels increased progressively during volume expansion with saline infusion, increasing by 18% after 30 min and by 93% after 120 min, and did not change during recumbency alone. 3. Plasma ANP levels immediately after a standard blood donation performed semirecumbent were significantly lower than before blood donation; they fell by 18%. 4. The magnitude of the fall in ANP induced by blood donation correlated significantly with basal plasma ANP. 5. In man, ANP responds to both increases and decreases in central blood volume, consistent with a role for ANP in blood volume homeostasis.

摘要

为了更好地确定急性中心容量调节对心房利钠肽（ANP）的影响程度，研究了生理盐水输注和放血对正常受试者心房利钠肽的影响。2. 在输注生理盐水进行容量扩张期间，血浆ANP水平逐渐升高，30分钟后升高18%，120分钟后升高93%，而仅在卧位时则无变化。3. 半卧位进行标准献血后即刻血浆ANP水平显著低于献血前；下降了18%。4. 献血引起的ANP下降幅度与基础血浆ANP显著相关。5. 在人类中，ANP对中心血容量的增加和减少均有反应，这与ANP在血容量稳态中的作用一致。