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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Klemm S A, Gordon R D, Tunny T J, Hawkins P G, Finn W L, Hamlet S M, Kewal N K, Purton K J

Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1989 Apr;16(4):269-74. doi: 10.1111/j.1440-1681.1989.tb01556.x.

In Bartter's syndrome, atrial pressures were low, consistent with volume contraction, while atrial natriuretic peptide (ANP) levels were unexpectedly elevated. Infusion of normal saline increased both right atrial pressure (RAP) and ANP levels, while administration of prostaglandin inhibitors raised RAP, probably due to volume expansion, but ANP levels fell paradoxically. 2. In Gordon's syndrome, atrial pressures were unexpectedly low or normal despite volume expansion, while ANP levels were normal. Pressor infusions of angiotensin II either raised right and left atrial pressures (LAP) without increasing ANP, or increased ANP without increasing atrial pressures. 3. In these two syndromes, atrial pressures and ANP levels were poorly correlated, leading to the proposal that other regulators of ANP may be important.

在巴特综合征中，心房压力较低，与容量收缩一致，而心房利钠肽（ANP）水平却意外升高。输注生理盐水可使右心房压力（RAP）和ANP水平均升高，而给予前列腺素抑制剂可使RAP升高，这可能是由于容量扩张所致，但ANP水平却反而下降。2. 在戈登综合征中，尽管存在容量扩张，但心房压力却意外地降低或正常，而ANP水平正常。血管紧张素II的升压输注要么使右心房和左心房压力（LAP）升高而不增加ANP，要么使ANP增加而不增加心房压力。3. 在这两种综合征中，心房压力与ANP水平相关性较差，这提示可能还有其他ANP调节因子发挥重要作用。

Klemm S A, Gordon R D, Tunny T J, Hawkins P G, Finn W L, Hamlet S M, Kewal N K, Purton K J

Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1989 Apr;16(4):269-74. doi: 10.1111/j.1440-1681.1989.tb01556.x.

In Bartter's syndrome, atrial pressures were low, consistent with volume contraction, while atrial natriuretic peptide (ANP) levels were unexpectedly elevated. Infusion of normal saline increased both right atrial pressure (RAP) and ANP levels, while administration of prostaglandin inhibitors raised RAP, probably due to volume expansion, but ANP levels fell paradoxically. 2. In Gordon's syndrome, atrial pressures were unexpectedly low or normal despite volume expansion, while ANP levels were normal. Pressor infusions of angiotensin II either raised right and left atrial pressures (LAP) without increasing ANP, or increased ANP without increasing atrial pressures. 3. In these two syndromes, atrial pressures and ANP levels were poorly correlated, leading to the proposal that other regulators of ANP may be important.

在巴特综合征中，心房压力较低，与容量收缩一致，而心房利钠肽（ANP）水平却意外升高。输注生理盐水可使右心房压力（RAP）和ANP水平均升高，而给予前列腺素抑制剂可使RAP升高，这可能是由于容量扩张所致，但ANP水平却反而下降。2. 在戈登综合征中，尽管存在容量扩张，但心房压力却意外地降低或正常，而ANP水平正常。血管紧张素II的升压输注要么使右心房和左心房压力（LAP）升高而不增加ANP，要么使ANP增加而不增加心房压力。3. 在这两种综合征中，心房压力与ANP水平相关性较差，这提示可能还有其他ANP调节因子发挥重要作用。