心力衰竭大鼠心房利钠肽输注后肾脏反应减弱。

Attenuated renal response to atrial natriuretic peptide infusion in rats with heart failure.

Kohzuki M, Hodsman G P, Harrison R W, Johnston C I

University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):323-6. doi: 10.1111/j.1440-1681.1988.tb01081.x.

Abstract

The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

摘要

在左冠状动脉结扎诱导心肌梗死后4周的大鼠中，研究了三种心房利钠肽（ANP）输注速率的利钠和利尿作用。2. 在对照组和梗死大鼠中观察到了ANP的利钠和利尿作用，但在后者中这些作用明显减弱。3. 与对照组相比，慢性左心衰竭大鼠对ANP的肾脏作用较不敏感。4. 慢性心力衰竭中钠和水排泄受损可能部分归因于肾脏对ANP的反应减弱。