School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, PR China.
Clin Chim Acta. 2018 Sep;484:52-59. doi: 10.1016/j.cca.2018.05.038. Epub 2018 May 19.
Several investigations have explored the prognostic value of long noncoding RNA Sox2 overlapping transcript (lncRNA Sox2ot) expression in human cancers, however, with inconsistent results. The aim of this study was to evaluate the prognostic role of lncRNA Sox2ot expression in various cancers.
PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to retrieve relevant studies. The relationships between lncRNA Sox2ot expression and prognostic parameters were detected, including overall survival (OS), tumor differentiation, clinical stage, distant metastasis, lymph node metastasis and so on.
A total of 10 studies involving 943 cancer patients were finally included into the study. High lncRNA Sox2ot expression was significantly related to shorter OS in cancers (HR = 2.06, 95%CI = 1.67-2.55, P < 0.01). The cancer patients with high lncRNA Sox2ot expression tended to have worse tumor differentiation (P = 0.04), advanced clinical stage (P < 0.01), earlier distant metastasis (P < 0.01), and earlier lymph node metastasis (P = 0.01) compared to those with low lncRNA Sox2ot expression. However, there was no distinct correlation between lncRNA Sox2ot expression and age (P = 0.87), gender (P = 0.48), tumor size (P = 0.08), or vascular invasion (P = 0.07).
High lncRNA Sox2ot expression was significantly associated with worse OS, advanced clinical stage, worse tumor differentiation, earlier distant metastasis, and earlier lymph node metastasis in various cancers. LncRNA Sox2ot expression might a promising prognostic factor in various cancers.
多项研究已经探讨了长非编码 RNA Sox2 重叠转录物（lncRNA Sox2ot）在人类癌症中的表达的预后价值，但结果不一致。本研究旨在评估 lncRNA Sox2ot 表达在各种癌症中的预后作用。
全面检索 PubMed、Web of Science、Embase 和 Cochrane Library 以检索相关研究。检测 lncRNA Sox2ot 表达与预后参数之间的关系，包括总生存期（OS）、肿瘤分化、临床分期、远处转移、淋巴结转移等。
最终纳入了 10 项共涉及 943 例癌症患者的研究。lncRNA Sox2ot 高表达与癌症患者的 OS 较短显著相关（HR=2.06，95%CI=1.67-2.55，P<0.01）。与 lncRNA Sox2ot 低表达的癌症患者相比，lncRNA Sox2ot 高表达的癌症患者肿瘤分化较差（P=0.04）、临床分期较高（P<0.01）、远处转移较早（P<0.01）、淋巴结转移较早（P=0.01）。然而，lncRNA Sox2ot 表达与年龄（P=0.87）、性别（P=0.48）、肿瘤大小（P=0.08）或血管侵犯（P=0.07）之间无明显相关性。
lncRNA Sox2ot 高表达与各种癌症中的 OS 较差、临床分期较高、肿瘤分化较差、远处转移较早和淋巴结转移较早显著相关。lncRNA Sox2ot 表达可能是各种癌症中有前途的预后因素。
