LncRNA GHET1 表达在多种癌症中的预后意义：系统评价和荟萃分析。
Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.
机构信息
Department of Medical Oncology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
Department of Traditional Chinese Internal Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of TCM, Hangzhou 310006, China.
出版信息
Biosci Rep. 2019 Oct 30;39(10). doi: 10.1042/BSR20190608.
BACKGROUND
Dysregulated expression of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA GHET1) has been observed in several cancers, however, definite conclusion on the prognostic value of lncRNA GHET1 expression in human cancers has not been determined. The aim of this meta-analysis was to evaluate the prognostic significance of lncRNA GHET1 expression in cancers.
METHODS
PubMed, Web of Science and Embase were comprehensively searched for relevant studies. Meta-analyses of overall survival (OS) and clinicopathological features were conducted.
RESULTS
Ten studies were finally analyzed in the present study. High lncRNA GHET1 expression was associated with shorter OS than low lncRNA GHET1 expression in cancers (hazard ratio (HR) = 2.59, 95% CI = 1.93-3.47, P<0.01). Online cross-validation using The Cancer Genome Atlas (TCGA) data observed similar results (HR = 1.10, P<0.05). When compared with low lncRNA GHET1 expression, high lncRNA GHET1 expression was related to larger tumor size (P<0.01), worse differentiation (P<0.01), earlier distant metastasis (P=0.02), earlier lymph node metastasis (P<0.01) and more advanced clinical stage (P<0.01).
CONCLUSION
High lncRNA GHET1 expression is associated with worse cancer prognosis and can serve as a promising prognostic factor of human cancers.
背景
长链非编码 RNA 胃癌高表达转录本 1（lncRNA GHET1）的表达失调已在多种癌症中观察到，然而，lncRNA GHET1 表达在人类癌症中的预后价值尚未得出明确结论。本荟萃分析旨在评估 lncRNA GHET1 表达在癌症中的预后意义。
方法
全面检索了 PubMed、Web of Science 和 Embase 中的相关研究。对总生存期（OS）和临床病理特征进行了荟萃分析。
结果
本研究最终分析了 10 项研究。在癌症中，高 lncRNA GHET1 表达与较短的 OS 相关，而低 lncRNA GHET1 表达则与较长的 OS 相关（风险比（HR）=2.59，95%置信区间（CI）=1.93-3.47，P<0.01）。使用癌症基因组图谱（TCGA）数据进行在线交叉验证也观察到了类似的结果（HR=1.10，P<0.05）。与低 lncRNA GHET1 表达相比，高 lncRNA GHET1 表达与更大的肿瘤大小（P<0.01）、较差的分化（P<0.01）、更早的远处转移（P=0.02）、更早的淋巴结转移（P<0.01）和更晚期的临床分期（P<0.01）相关。
结论
高 lncRNA GHET1 表达与癌症预后较差相关，可作为人类癌症有前途的预后因素。
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