儿童耐多药结核病治疗中左氧氟沙星长期应用的临床与心脏安全性。
Clinical and Cardiac Safety of Long-term Levofloxacin in Children Treated for Multidrug-resistant Tuberculosis.
机构信息
Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University.
出版信息
Clin Infect Dis. 2018 Nov 13;67(11):1777-1780. doi: 10.1093/cid/ciy416.
Abstract
Safety concerns persist for long-term pediatric fluoroquinolone use. Seventy children (median age, 2.1 years) treated with levofloxacin 10-20 mg/kg once daily for multidrug-resistant tuberculosis (median observation time, 11.8 months) had few musculoskeletal events, no levofloxacin-attributed serious adverse events, and no Fridericia-corrected QT interval >450 ms. Long-term levofloxacin was safe and well tolerated.
摘要
长期使用儿科氟喹诺酮类药物的安全性问题仍然存在。70 名儿童（中位年龄 2.1 岁）接受左氧氟沙星 10-20mg/kg 每日一次治疗耐多药结核病（中位观察时间 11.8 个月），很少发生肌肉骨骼事件，无左氧氟沙星相关严重不良事件，且无 Fridericia 校正 QT 间期>450ms。长期使用左氧氟沙星是安全且耐受良好的。
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