Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University.
Clin Infect Dis. 2018 Nov 13;67(11):1777-1780. doi: 10.1093/cid/ciy416.
Safety concerns persist for long-term pediatric fluoroquinolone use. Seventy children (median age, 2.1 years) treated with levofloxacin 10-20 mg/kg once daily for multidrug-resistant tuberculosis (median observation time, 11.8 months) had few musculoskeletal events, no levofloxacin-attributed serious adverse events, and no Fridericia-corrected QT interval >450 ms. Long-term levofloxacin was safe and well tolerated.
长期使用儿科氟喹诺酮类药物的安全性问题仍然存在。70 名儿童（中位年龄 2.1 岁）接受左氧氟沙星 10-20mg/kg 每日一次治疗耐多药结核病（中位观察时间 11.8 个月），很少发生肌肉骨骼事件，无左氧氟沙星相关严重不良事件，且无 Fridericia 校正 QT 间期>450ms。长期使用左氧氟沙星是安全且耐受良好的。
