Adler-Shohet Felice C, Low Julie, Carson Michael, Girma Haimanot, Singh Jasjit
From the *Infectious Diseases, Children's Hospital Orange County, Orange; and † County of Orange Health Care Agency, Santa Ana, CA.
Pediatr Infect Dis J. 2014 Jun;33(6):664-6. doi: 10.1097/INF.0000000000000260.
After exposure to a teacher with multidrug-resistant pulmonary tuberculosis, 31 children developed latent infection. Twenty-six were treated with levofloxacin and pyrazinamide. Twelve required a change in therapy secondary to adverse effects. The most common adverse effects included abdominal pain, arthralgias/myalgias and elevated transaminases. All children reported at least 1 adverse effect. Fifteen children completed treatment. All adverse effects were transient.
在接触了一名耐多药肺结核教师后，31名儿童发生了潜伏感染。26名儿童接受了左氧氟沙星和吡嗪酰胺治疗。12名儿童因不良反应需要更换治疗方案。最常见的不良反应包括腹痛、关节痛/肌肉痛和转氨酶升高。所有儿童均报告至少出现1种不良反应。15名儿童完成了治疗。所有不良反应都是暂时的。
