基于磁性纳米粒子的分子探针在肝细胞癌诊断与治疗中的最新进展。
Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy.
机构信息
Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, You An Men Wai, Feng Tai District, Beijing 100069, China.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
出版信息
Curr Pharm Des. 2018;24(21):2432-2437. doi: 10.2174/1381612824666180516111939.
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demonstrating great potential and promising in vivo applications. This review focuses on the use of different magnetic nanoparticles for construction of HCC nanoprobes for MR imaging and theranostic purpose.
肝细胞癌（HCC）是全球最常见的癌症之一，也是癌症相关死亡的第二大主要原因。医学影像学在 HCC 的筛查和诊断中至关重要。由于具有相对较高的特殊分辨率和出色的灵敏度，基于磁性纳米颗粒的对比剂的磁共振成像（MRI）迄今为止已用于 HCC 成像和分期，在体内应用方面显示出巨大的潜力和广阔的前景。本综述重点介绍了不同磁性纳米颗粒在构建用于 MRI 成像和治疗目的的 HCC 纳米探针中的应用。
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