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基于石墨烯量子点的磁性壳聚糖载药纳米系统用于靶向协同光热-化学治疗肝癌。

Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma.

机构信息

Department of Orthopedics, Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Hangzhou Medical College Affiliated Chun'an Hospital, Hangzhou, P.R. China.

Clinical laboratory of Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Hangzhou Medical College Affiliated Chun'an Hospital, Hangzhou, P.R. China.

出版信息

Cancer Biol Ther. 2022 Dec 31;23(1):281-293. doi: 10.1080/15384047.2022.2054249.

DOI:10.1080/15384047.2022.2054249
PMID:35323086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8959518/
Abstract

Conventional clinical monotherapies for advanced hepatocellular carcinoma (HCC) have numerous limitations. Integrated oncology approaches can improve cancer treatment efficacy, and photothermal-chemotherapy drug delivery nanosystems (DDS) based on nanotechnology and biotechnology have piqued the interest of researchers. This study developed an aptamer-modified graphene quantum dots (GQDs)/magnetic chitosan DDS for photothermal-chemotherapy of HCC. The HCC aptamer and the EPR effect of nanoparticles, in particular, enable active and passive targeting of DDS to HCC. GQDs functioned as photosensitizers, effectively moderating photothermal therapy and inhibiting drug release during blood circulation. Magnetic chitosan demonstrated excellent drug encapsulation, acid sensitivity, and tumor imaging capabilities. Proper assembly of the units mentioned above enables precise combined therapy of HCC. This study indicates that DDS can significantly inhibit tumor growth while also extending the survival duration of tumor-bearing mice. The DDS (DOX-FeO@CGA) shows strong synergistic tumor treatment potential, allowing for the exploration and development of novel HCC therapies.

摘要

传统的晚期肝细胞癌 (HCC) 临床单药治疗存在诸多局限性。综合肿瘤学方法可以提高癌症治疗效果，基于纳米技术和生物技术的光热化疗药物递送纳米系统 (DDS) 引起了研究人员的兴趣。本研究开发了一种适体修饰的石墨烯量子点 (GQDs)/磁性壳聚糖 DDS，用于 HCC 的光热化疗。HCC 适体和纳米颗粒的 EPR 效应，特别是使 DDS 对 HCC 的主动和被动靶向成为可能。GQDs 作为光热剂，有效调节光热治疗，并在血液循环过程中抑制药物释放。磁性壳聚糖表现出良好的药物包封、酸敏感性和肿瘤成像能力。上述单元的适当组装能够实现 HCC 的精确联合治疗。本研究表明，DDS 可显著抑制肿瘤生长，同时延长荷瘤小鼠的存活时间。DDS（DOX-FeO@CGA）显示出很强的协同肿瘤治疗潜力，为探索和开发新型 HCC 治疗方法提供了可能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/fad05d1ce4b2/KCBT_A_2054249_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e6efb448b269/KCBT_A_2054249_SCH0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/183f867952b8/KCBT_A_2054249_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/d043989461b5/KCBT_A_2054249_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e2c04cdcf306/KCBT_A_2054249_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/fe561b39cd07/KCBT_A_2054249_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/3e3020b6cccc/KCBT_A_2054249_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/4680f01fb460/KCBT_A_2054249_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e87110a8cb49/KCBT_A_2054249_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/fad05d1ce4b2/KCBT_A_2054249_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e6efb448b269/KCBT_A_2054249_SCH0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/183f867952b8/KCBT_A_2054249_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/d043989461b5/KCBT_A_2054249_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e2c04cdcf306/KCBT_A_2054249_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/fe561b39cd07/KCBT_A_2054249_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/3e3020b6cccc/KCBT_A_2054249_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/4680f01fb460/KCBT_A_2054249_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/e87110a8cb49/KCBT_A_2054249_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/8959518/fad05d1ce4b2/KCBT_A_2054249_F0009_OC.jpg

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