Rapp J P, Dene H
Department of Medicine, Medical College of Ohio, Toledo 43699.
Cardiovasc Drugs Ther. 1988 Nov;2(4):487-91. doi: 10.1007/BF00051187.
Dahl salt-sensitive (S) rats on normal salt intake develop a chronic form of hypertension with aging whereas Dahl salt-resistant (R) rats do not. In old hypertensive S rats the left ventricle is recruited for the production of ANF as evidenced by a seven- to ten-fold increase in atrial natriuretic factor (ANF) mRNA and increased ANF in ventricular tissue. Plasma ANF is also markedly increased in hypertensive S rats but there is no direct proof that ventricular production of ANF contributes to high plasma ANF. Atrial ANF is higher in S than R rats but this strain difference is not associated with strain differences in ANF mRNA in atria and atrial ANF mRNA does not increase dramatically in hypertensive S rats as does ventricular mRNA. Recruitment of the ventricle to produce ANF is clearly a secondary consequence of hypertension, but its functional significance is not established.
正常盐摄入的 Dahl 盐敏感（S）大鼠随着年龄增长会发展为慢性高血压，而 Dahl 盐抵抗（R）大鼠则不会。在老年高血压 S 大鼠中，左心室参与心房钠尿肽（ANF）的产生，这可通过心室组织中心房钠尿肽（ANF）mRNA 增加 7 至 10 倍以及 ANF 增加得到证明。高血压 S 大鼠的血浆 ANF 也显著增加，但尚无直接证据表明心室产生的 ANF 导致血浆 ANF 升高。S 大鼠的心房 ANF 高于 R 大鼠，但这种品系差异与心房中 ANF mRNA 的品系差异无关，且高血压 S 大鼠的心房 ANF mRNA 不会像心室 mRNA 那样显著增加。心室参与产生 ANF 显然是高血压的次要后果，但其功能意义尚未明确。
