Tanaka I, Inagami T
J Hypertens. 1986 Feb;4(1):109-12. doi: 10.1097/00004872-198602000-00017.
In order to determine whether there is a relationship between genetically determined salt-induced hypertension and atrial natriuretic factor (ANF), a radio-immunoassay for ANF was applied to the determination of immunoreactive ANF in plasma, atrium, hypothalamus and pons of Dahl salt-sensitive (S) and -resistant (R) rats which were fed high- or low-salt diet for 7 weeks. A twofold higher concentration of plasma ANF was observed in high-salt S rats, which developed hypertension, compared with low-salt S rats or R rats on high or low salt, which were normotensive. No significant difference was seen in atrial concentrations of ANF between S and R rats. The brain ANF concentration of the high-salt group was lower than that of the low-salt group in both S and R rats. It is proposed that the elevation of plasma ANF in the hypertensive rats may reflect a compensatory mechanism induced by volume expansion in the salt-fed S rats.
为了确定基因决定的盐诱导性高血压与心钠素（ANF）之间是否存在关系，采用放射免疫分析法测定了经7周高盐或低盐饮食喂养的Dahl盐敏感（S）大鼠和盐抵抗（R）大鼠血浆、心房、下丘脑和脑桥中免疫反应性ANF的含量。与低盐S大鼠或高盐或低盐饮食的血压正常的R大鼠相比，发生高血压的高盐S大鼠血浆ANF浓度高出两倍。S大鼠和R大鼠心房中ANF浓度未见显著差异。在S大鼠和R大鼠中，高盐组的脑ANF浓度均低于低盐组。研究表明，高血压大鼠血浆ANF升高可能反映了盐喂养的S大鼠因容量扩张诱导的一种代偿机制。
