Garcia R, Thibault G, Gutkowska J, Hamet P, Cantin M, Genest J
Proc Soc Exp Biol Med. 1985 Jan;178(1):155-9. doi: 10.3181/00379727-178-rc12.
Conscious two-kidney, one-clip hypertensive rats were chronically infused during 7 days with synthetic ANF (8-33) (1 microgram/hr/rat) by means of osmotic minipumps. The initial blood pressure of 183 +/- 4 mmHg gradually decreased to 116 +/- 5 mmHg the last 2 days of infusion. Pressure diuresis returned to normal and pressure natriuresis was attenuated. PRA was significantly lower (1.81 +/- 0.41 AI ng/ml/hr) than in not treated hypertensive rats (8.56 +/- 3.75 AI ng/ml/hr). A partial regression in cardiac hypertrophy was observed in the treated group. We suggest that the hypotensive response to ANF may be mainly due to vasodilatation, but the possibility that the decrease in PRA may play a partial role in lowering blood pressure, cannot be excluded.
清醒的两肾一夹高血压大鼠通过渗透微型泵连续7天慢性输注合成心房钠尿肽（8 - 33）（1微克/小时/大鼠）。输注开始时血压为183±4毫米汞柱，在输注的最后两天逐渐降至116±5毫米汞柱。压力利尿恢复正常，压力排钠减弱。血浆肾素活性（PRA）显著低于未治疗的高血压大鼠（1.81±0.41 AI纳克/毫升/小时 vs 8.56±3.75 AI纳克/毫升/小时）。在治疗组中观察到心脏肥大部分消退。我们认为，对心房钠尿肽的降压反应可能主要是由于血管舒张，但不能排除PRA降低可能在降低血压中起部分作用的可能性。
