Natochin Yu V, Kutina A V, Marina A S, Shakhmatova E I
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Dokl Biol Sci. 2018 Mar;479(1):57-59. doi: 10.1134/S0012496618020084. Epub 2018 May 22.
Blood concentration of glucagon-like peptide-1 (GLP-1) increased 5 min after per os administration of water, sodium chloride solution, or glucose solution. Changes in blood osmolality or blood glucose level did not stimulate GLP-1 release. A method of short-term increase in the gastric capacity in rats using an inflating balloon attached to the Foley catheter was developed in order to test the hypothesis that excitation of the upper gastrointestinal tract receptors is a primary signal for the GLP-1 secretion during oral intake of the substances. Mechanical gastric distension in rats caused elevation of the blood GLP-1 concentration which was comparable to the effects of oral administration of water, sodium chloride, and glucose solutions.
口服水、氯化钠溶液或葡萄糖溶液5分钟后，胰高血糖素样肽-1（GLP-1）的血药浓度升高。血渗透压或血糖水平的变化并未刺激GLP-1释放。为了验证上消化道受体的兴奋是口服这些物质期间GLP-1分泌的主要信号这一假设，开发了一种使用连接到Foley导管的充气气球短期增加大鼠胃容量的方法。大鼠的机械性胃扩张导致血GLP-1浓度升高，这与口服水、氯化钠和葡萄糖溶液的效果相当。
