Ruggeri Jessica, Foresti Fabio, Pavesi Roberta, Terrini Alessia, Giudici Francesca, Padoan Diego, Corradi Attilio, Ossiprandi Maria Cristina, Pasquali Paolo, Alborali Giovanni Loris
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna [Experimental Zooprophylactic Institute of Lombardy and Emilia Romagna], 25124, Brescia, Italy.
GKL S.a.s, Casalfiumanese (Bo), Casalfiumanese, Italy.
Vet Res Commun. 2018 Sep;42(3):209-217. doi: 10.1007/s11259-018-9723-3. Epub 2018 May 22.
Salmonella Typhimurium (including S.Typhimurium 1,4,[5],12:i-) and other enteric pathogens cause acute infection in pigs during the weaning stage, often evolving into chronic infections responsible for the introduction of zoonotic bacteria into the slaughterhouse and thus determining carcass contamination. In addition to being zoonotic hazards, these pathogens are responsible for economic losses in affected farms. Traditionally, antibiotic treatments have been largely administered in order to reduce the infection burden but it favored, as a direct consequence, an increase in the number of multi-drug resistance strains. In order to overcome antibiotic-resistance concerns, new alternative control strategies should be developed. In this context, a blend of organic acids, phytochemicals and a permeabilizing complex, administered in feed (Group A - 459 piglets) or water (Group B - 458 piglets), was tested in field conditions for its capability of reducing Salmonella-infection in weaned piglets of an endemic farm. Data recorded were compared to results of a control group (Group C - 456 piglets). Zootechnical parameters were recorded in all animals, while microbiological, serological and PCR analyses were conducted in 15 piglets for each group. Results demonstrated that additive administered in feed improved animal weight gain (better average daily gain [A.D.G.] and increment), and rapidly reduced Salmonella-shedding in feces. Administration of additive in feed gave better results than in water.
鼠伤寒沙门氏菌（包括1,4,[5],12:i-型鼠伤寒沙门氏菌）和其他肠道病原体在断奶阶段会引发猪的急性感染，常常演变成慢性感染，导致人畜共患病细菌进入屠宰场，进而造成胴体污染。这些病原体不仅是人畜共患病危害源，还会给受影响的养殖场带来经济损失。传统上，为了减轻感染负担，大量使用抗生素治疗，但这直接导致了多重耐药菌株数量的增加。为了克服对抗生素耐药性的担忧，应开发新的替代控制策略。在此背景下，将一种有机酸、植物化学物质和一种渗透复合物的混合物通过饲料（A组 - 459头仔猪）或饮水（B组 - 458头仔猪）投喂，在田间条件下测试其降低某地方性猪场断奶仔猪沙门氏菌感染的能力。记录的数据与对照组（C组 - 456头仔猪）的结果进行比较。记录了所有动物的畜牧学参数，同时对每组15头仔猪进行了微生物学、血清学和PCR分析。结果表明，通过饲料投喂添加剂可提高动物体重增加（更好的平均日增重[A.D.G.]和增量），并迅速减少粪便中沙门氏菌的排出。通过饲料投喂添加剂的效果优于饮水投喂。
