James J. Peters Veterans' Administration Medical Center, Bronx, NY, USA.
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Acta Psychiatr Scand. 2018 Jul;138(1):55-61. doi: 10.1111/acps.12897. Epub 2018 May 22.
The goal of this study was to determine whether combat veterans who have made a suicide attempt postdeployment can be distinguished from combat veterans who have never made a suicide attempt based on differences in psychological and biological variables.
Demographic and clinical parameters of suicide attempters and non-attempters were assessed. Blood samples were assayed for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS).
Suicide attempters had higher Scale for Suicidal Ideation and Montgomery-Åsberg Depression Rating Scale (MADRS)-suicidal thoughts item scores in comparison with non-attempters. There was a trend toward higher MADRS scores in the suicide attempter group compared with non-attempters. Suicide attempters had significantly lower levels of DHEA and DHEAS compared with non-attempters. Scale for Suicidal Ideation scores in all study participants combined negatively correlate with DHEA and DHEAS levels. DHEAS levels negatively correlate with Scale for Suicidal Ideation scores in suicide non-attempters but not in suicide attempters. DHEA/DHEAS ratios positively correlate with total adolescence aggression scores, total adulthood aggression scores, and total aggression scale scores in suicide attempters but not in suicide non-attempters.
There are psychobiological differences between combat veterans with or without a history of suicidal behaviour.
本研究旨在确定经历过战斗的、有过自杀未遂经历的退伍军人是否可以通过心理和生物变量的差异与从未有过自杀企图的退伍军人区分开来。
评估自杀未遂者和非自杀未遂者的人口统计学和临床参数。检测脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）的血样。
与非自杀未遂者相比，自杀未遂者的自杀意念量表和蒙哥马利-阿斯伯格抑郁评定量表（MADRS）-自杀想法项目评分更高。与非自杀未遂者相比，自杀未遂者的 MADRS 评分呈上升趋势。与非自杀未遂者相比，自杀未遂者的 DHEA 和 DHEAS 水平明显较低。所有研究参与者的自杀意念量表评分与 DHEA 和 DHEAS 水平呈负相关。DHEAS 水平与自杀非未遂者的自杀意念量表评分呈负相关，但与自杀未遂者无关。DHEA/DHEAS 比值与自杀未遂者的青春期总攻击评分、成年期总攻击评分和总攻击量表评分呈正相关，但与自杀非未遂者无关。
有自杀行为史的经历过战斗的退伍军人与没有自杀行为史的退伍军人之间存在心理生物学差异。
