James J. Peters Veterans' Administration Medical Center, Bronx, NY, USA; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
James J. Peters Veterans' Administration Medical Center, Bronx, NY, USA; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Psychiatry Res. 2020 May;287:112495. doi: 10.1016/j.psychres.2019.112495. Epub 2019 Jul 25.
Combat veterans are at elevated suicide risk. The goal of this study was to test the hypothesis that combat veterans who have made a suicide attempt post-deployment can be distinguished from combat veterans who have never made a suicide attempt based on differences in psychological and biological variables. For the latter, we focused on endogenous cannabinoids, neuroendocrine markers that are associated with stress. Demographic and clinical parameters of suicide attempters and non-attempters were assessed. Blood samples were assayed for anandamide (AEA), 2-arachidonoylglycerol (2-AG), and cortisol. Suicide attempters had higher Scale for Suicidal Ideation (SSI) scores in comparison to non-attempters. Controlling for gender, 2-AG levels were higher among suicide attempters in comparison to non-attempters. Cortisol levels positively correlated with 2-AG levels and negatively correlated with SSI scores among non-attempters but not among attempters. AEA levels negatively correlated with SSI scores among attempters but not among non-attempters. Our results indicate that there are psychological and biological differences between combat veterans with or without a history of suicidal attempt. Our findings also suggest that clinically observed differences between the groups may have a neurobiological basis.
参战老兵的自杀风险较高。本研究旨在验证以下假设：与从未尝试过自杀的参战老兵相比，已在部署后尝试过自杀的参战老兵在心理和生物变量上存在差异。对于后者，我们重点关注内源性大麻素，这些神经内分泌标志物与应激有关。评估了自杀未遂者和非自杀未遂者的人口统计学和临床参数。对血液样本进行了检测，以分析花生四烯酸乙醇胺（AEA）、2-花生四烯酸甘油（2-AG）和皮质醇的含量。与非自杀未遂者相比，自杀未遂者的自杀意念量表（SSI）评分更高。控制性别后，与非自杀未遂者相比，自杀未遂者的 2-AG 水平更高。非自杀未遂者的皮质醇水平与 2-AG 水平呈正相关，与 SSI 评分呈负相关，但自杀未遂者的皮质醇水平与 2-AG 水平和 SSI 评分均无相关性。AEA 水平与自杀未遂者的 SSI 评分呈负相关，但与非自杀未遂者的 SSI 评分无相关性。我们的研究结果表明，有过自杀未遂史的参战老兵和没有过自杀未遂史的参战老兵之间存在心理和生物学差异。我们的研究结果还表明，临床观察到的两组之间的差异可能具有神经生物学基础。
