Shen Songjie, Xu Qianqian, Zhou Yidong, Mao Feng, Guan Jinghong, Sun Qiang
Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China.
J Surg Oncol. 2018 Jun;117(8):1841-1847. doi: 10.1002/jso.25058. Epub 2018 May 22.
There were limited data available for a head-to-head comparison of the identification rate and survival between the combined method of indocyanine green fluorescence and blue dye versus the traditional blue dye alone method for sentinel lymph node (SLN) biopsy.
From January 2013 to December 2015, 523 eligible breast cancer patients were included in this nonrandomized prospective analysis. The identification rates, the number of SLNs identified, and the disease-free survival (DFS) between the two mapping methods were compared.
The identification rate of SLNs was significantly higher with the combined method than that with the blue dye alone method (99.2% vs 93.3%, respectively; P < 0.001). The average number of SLNs identified per patient in the combined method group was 3.7 ± 2.4, which was more than that in the blue dye alone group (3.2 ± 1.6; P = 0.004). With a median follow-up of 29 months, 0.5% patients in the combined group, and 1.3% patients in the blue dye group had axillary recurrences. The DFS between the two groups showed no significant difference (P = 0.161).
The combined method achieved a higher identification rate and lower rate of axillary recurrence compared to the blue dye alone method.
对于吲哚菁绿荧光与蓝色染料联合法和传统单纯蓝色染料法在前哨淋巴结（SLN）活检中的识别率及生存率的直接比较，可用数据有限。
2013年1月至2015年12月，523例符合条件的乳腺癌患者纳入该非随机前瞻性分析。比较两种定位方法的识别率、识别出的SLN数量及无病生存率（DFS）。
联合法对SLN的识别率显著高于单纯蓝色染料法（分别为99.2%和93.3%；P＜0.001）。联合法组每位患者识别出的SLN平均数量为3.7±2.4，多于单纯蓝色染料组（3.2±1.6；P = 0.004）。中位随访29个月时，联合组0.5%的患者和蓝色染料组1.3%的患者出现腋窝复发。两组间的DFS无显著差异（P = 0.161）。
与单纯蓝色染料法相比，联合法具有更高的识别率和更低的腋窝复发率。
