阿可乐定预防钕激光后囊切开术后眼压升高的有效性。
Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy.
作者信息
Pollack I P, Brown R H, Crandall A S, Robin A L, Stewart R H, White G L
机构信息
Wilmer Ophthalmology Institute, Department of Ophthalmology, Johns Hopkins University, Baltimore.
出版信息
Trans Am Ophthalmol Soc. 1988;86:461-72.
Apraclonidine (para-aminoclonidine) is an alpha agonist that was studied for its effect on the IOP rise following YPC. In a prospective multicentered double-masked study 63 eyes were pretreated with one drop of either 1% apraclonidine or placebo 1 hour prior to performing YAG and again after the laser treatment. The greatest IOP rise in the placebo-treated eyes occurred in the third hour after YPC when the mean IOP rose from a baseline pressure of 16.4 +/- 3.7 mm Hg to 20.8 +/- 6.8 mm Hg (P less than .01). In apraclonidine-treated eyes the IOP fell from a mean of 15.6 +/- 3.8 mm Hg to 12.8 +/- 6.0 mm Hg 3 hours postoperatively (P less than .001). There were five times as many eyes that had a pressure rise greater than 10 mm Hg in the placebo-treated group compared to those treated with apraclonidine. Apraclonidine proved to be highly effective in preventing the rise in IOP following YPC.
阿可乐定（对氨基可乐定）是一种α激动剂，已对其在YAG激光周边虹膜切开术（YPC）后眼压升高方面的作用进行了研究。在一项前瞻性多中心双盲研究中，63只眼睛在进行YAG激光治疗前1小时以及激光治疗后分别滴入一滴1%阿可乐定或安慰剂。安慰剂治疗组眼睛的最大眼压升高出现在YPC后的第3小时，此时平均眼压从基线压力16.4±3.7毫米汞柱升至20.8±6.8毫米汞柱（P<0.01）。在阿可乐定治疗组的眼睛中，术后3小时眼压从平均15.6±3.8毫米汞柱降至12.8±6.0毫米汞柱（P<0.001）。与阿可乐定治疗组相比，安慰剂治疗组中眼压升高超过10毫米汞柱的眼睛数量是其5倍。阿可乐定被证明在预防YPC后眼压升高方面非常有效。
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