阿可乐定滴眼液（Iopidine）对疑似硅油诱导性青光眼和原发性开角型青光眼的疗效。
Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma.
作者信息
Gramer E, Busche S, Kampik A, Parsons D
机构信息
University Eye Hospital, Würzburg, Germany.
出版信息
Graefes Arch Clin Exp Ophthalmol. 1995 Jan;233(1):13-20. doi: 10.1007/BF00177780.
BACKGROUND
This pilot study evaluated the acute effects of topical ocular apraclonidine 1% (Iopidine) in 10 patients with presumed silicone oil-induced secondary glaucoma (SOIG) and in 10 patients with high-pressure primary open-angle glaucoma (POAG) despite maximum tolerated medical therapy.
METHODS
Intraocular pressure (IOP) measurements were carried out before and 1, 2 and 3 h after a single drop of apraclonidine.
RESULTS
Patients with SIOG presented with a mean IOP of 30.0 +/- 2.8 mmHg, which was reduced to 21.7 +/- 2.9 mmHg (P < 0.001) after 1 h, to 20.4 +/- 2.3 mmHg (P < 0.001) after 2 h and to 20.0 +/- 2.5 mmHg (P < 0.001) after 3 h. In the POAG group, IOP was reduced from 25.9 +/- 1.9 mmHg before treatment to 18.9 +/- 1.4 mmHg after 1 h (P < 0.001), 17.7 +/- 1.2 mmHg after 2 h (P < 0.001) and 16.9 +/- 0.9 mmHg after 3 h (P < 0.001). There were no significant changes in blood pressure or pulse rate.
CONCLUSION
This study confirmed the activity of apraclonidine as an IOP suppressant.
背景
本初步研究评估了局部应用1%阿可乐定（Iopidine）对10例疑似硅油诱导性继发性青光眼（SOIG）患者和10例尽管接受了最大耐受药物治疗但眼压仍高的原发性开角型青光眼（POAG）患者的急性影响。
方法
在滴入一滴阿可乐定之前以及之后1、2和3小时测量眼压（IOP）。
结果
SOIG患者的平均眼压为30.0±2.8 mmHg，1小时后降至21.7±2.9 mmHg（P<0.001），2小时后降至20.4±2.3 mmHg（P<0.001），3小时后降至20.0±2.5 mmHg（P<0.001）。在POAG组中，眼压从治疗前的25.9±1.9 mmHg降至1小时后的18.9±1.4 mmHg（P<0.001），2小时后降至17.7±1.2 mmHg（P<0.001），3小时后降至16.9±0.9 mmHg（P<0.001）。血压和脉搏率无显著变化。
结论
本研究证实了阿可乐定作为眼压抑制剂的活性。
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