Salimzadeh Ahmad, Alipoor Elham, Dehghani Sahar, Yaseri Mehdi, Hosseini Mostafa, Feinle-Bisset Christine, Hosseinzadeh-Attar Mohammad Javad
Rheumatology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Int J Clin Pract. 2018 Jun;72(6):e13208. doi: 10.1111/ijcp.13208. Epub 2018 May 23.
Chronic joint pain and stiffness, and functional disability, are the major debilitating features of osteoarthritis (OA). The aim of this study was to assess the effect of 12-week supplementation with a garlic supplement on knee osteoarthritis outcomes in overweight or obese women.
Seventy-six postmenopausal overweight or obese women (25≤BMI≤40 kg/m ) with medically diagnosed knee OA participated in this randomised double-blind, placebo-controlled, parallel-design trial. After randomisation into 2 groups, patients received a daily dose of either 1000 mg odourless garlic tablet, or placebo, for 12 weeks. The total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), as well as pain, stiffness and physical function subscales, were evaluated pre- and poststudy. Anthropometric parameters and body composition (using bioelectrical impedance analysis) were also assessed.
Following 12-week supplementation in overweight or obese women with OA, stiffness (but not pain, function or WOMAC total score) was significantly lower in the garlic group compared with the placebo group (1.4 ± 1.6 vs 2.5 ± 1.9, P = .023). The changes in WOMAC parameters showed no statistically significant differences between the 2 groups. WOMAC total score (38.4 ± 15.9-30.6 ± 15.7, P = .004) and all the subscales, including pain (8.3 ± 3.7-7 ± 4.4, P = .026), stiffness (2.3 ± 1.6-1.4 ± 1.6, P = .013) and physical function (27.7 ± 11.9-22.2 ± 12.4, P = .001) improved significantly in the garlic group postintervention compared with pre-intervention; although pain subscale also decreased in the placebo group (9.6 ± 3.1-6.9 ± 3.7, P < .001).
Although pre- to postintervention knee OA symptoms were improved in overweight or obese women receiving 12 weeks garlic supplement, there was no significant difference in WOMAC changes compared with the placebo group. Further clinical trials are required to investigate the therapeutic value of garlic ingredients, and the potential role of placebo effect, in the management of OA symptoms.
慢性关节疼痛、僵硬以及功能障碍是骨关节炎（OA）的主要致残特征。本研究旨在评估超重或肥胖女性补充大蒜制剂12周对膝骨关节炎结局的影响。
76名经医学诊断为膝骨关节炎的绝经后超重或肥胖女性（25≤体重指数≤40kg/m²）参与了这项随机双盲、安慰剂对照、平行设计试验。随机分为两组后，患者每天服用1000mg无味大蒜片或安慰剂，持续12周。在研究前后评估了西安大略和麦克马斯特大学骨关节炎指数（WOMAC）总分以及疼痛、僵硬和身体功能分量表。还评估了人体测量参数和身体成分（使用生物电阻抗分析）。
超重或肥胖的OA女性补充12周后，大蒜组的僵硬程度（但疼痛、功能或WOMAC总分未改善）显著低于安慰剂组（1.4±1.6对2.5±1.9，P = 0.023）。两组间WOMAC参数变化无统计学显著差异。与干预前相比，大蒜组干预后WOMAC总分（38.4±15.9 - 30.6±15.7，P = 0.004）以及所有分量表，包括疼痛（8.3±3.7 - 7±4.4，P = 0.026）、僵硬（2.3±1.6 - 1.4±1.6，P = 0.013）和身体功能（27.7±11.9 - 22.2±12.4，P = 0.001）均显著改善；尽管安慰剂组的疼痛分量表也有所下降（9.6±3.1 - 6.9±3.7，P < 0.001）。
尽管接受12周大蒜补充剂的超重或肥胖女性干预前后膝骨关节炎症状有所改善，但与安慰剂组相比，WOMAC变化无显著差异。需要进一步的临床试验来研究大蒜成分在OA症状管理中的治疗价值以及安慰剂效应的潜在作用。
