Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Institute of Advanced Synthesis, Jiangsu National Synergetic Innovation Center for Advanced Materials , Nanjing Tech University , Nanjing 210009 , P. R. China.
Org Lett. 2018 Jun 1;20(11):3215-3219. doi: 10.1021/acs.orglett.8b01067. Epub 2018 May 23.
A practical and effective copper-catalyzed dehydrogenative Diels-Alder reaction of gem-diesters and ketone with dienes has been established. The active dienophiles were generated in situ via a radical-based dehydrogenation process, which reacted with a wide variety of dienes to afford various polysubstituted cyclohexene derivatives in good to excellent yields.
建立了一种实用且有效的铜催化的偕二酯和酮与二烯的脱氢 Diels-Alder 反应。活性亲双烯体通过基于自由基的脱氢过程原位生成，与各种二烯反应以良好至优异的收率得到各种多取代环己烯衍生物。
