Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China.
Guangdong Provincial Key Laboratory of Construction & Detection in Tissue Engineering, Guangzhou 510515, China.
Nanomedicine (Lond). 2018 May;13(9):1067-1085. doi: 10.2217/nnm-2017-0389. Epub 2018 May 23.
The ability to surgically repair peripheral nerve injuries is urgently needed. However, traditional tissue engineering techniques, such as autologous nerve transplantation, have some limitations. Therefore, tissue engineered autologous nerve grafts have become a suitable choice for nerve repair. Novel tissue engineering techniques derived from nanostructured conduits have been shown to be superior to other successful functional neurological structures with different scaffolds in terms of providing the required structures and properties. Additionally, different biomaterials and growth factors have been added to nerve scaffolds to produce unique biological effects that promote nerve regeneration and functional recovery. This review summarizes the application of different nanoscaffolds in peripheral nerve repair and further analyzes how the nanoscaffolds promote peripheral nerve regeneration.
迫切需要能够进行外周神经损伤修复的手术。然而，传统的组织工程技术，如自体神经移植，存在一些局限性。因此，组织工程化自体神经移植物已成为修复神经的合适选择。新型组织工程技术来源于纳米结构导管，已被证明在提供所需的结构和特性方面优于其他具有不同支架的成功功能性神经结构。此外，不同的生物材料和生长因子已被添加到神经支架中，以产生独特的生物效应，促进神经再生和功能恢复。本综述总结了不同纳米支架在外周神经修复中的应用，并进一步分析了纳米支架如何促进外周神经再生。
