使用网格进行 MeSH 术语富集和语义分析。
Using meshes for MeSH term enrichment and semantic analyses.
机构信息
Institute of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
State Key Laboratory of Emerging Infectious Disease, School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
出版信息
Bioinformatics. 2018 Nov 1;34(21):3766-3767. doi: 10.1093/bioinformatics/bty410.
SUMMARY
Medical Subject Headings (MeSH) is the NLM controlled vocabulary used to manually index articles for MEDLINE/PubMed. MeSH provides unique and comprehensive annotations for life science. The meshes package implements measurement of the semantic similarity of MeSH terms and gene products to help using MeSH vocabulary in knowledge mining. Enrichment analysis to extract the biological meanings from gene list, expression profile and genomic regions is also provided using MeSH annotation. Meshes supports more than 70 species and provides high quality visualization methods to help interpreting analysis results.
AVAILABILITY AND IMPLEMENTATION
meshes is released under Artistic-2.0 License. The source code and documents are freely available through Bioconductor (https://www.bioconductor.org/packages/meshes).
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
医学主题词（MeSH）是 NLM 受控词汇，用于手动为 MEDLINE/PubMed 中的文章编制索引。MeSH 为生命科学提供了独特而全面的注释。meshes 包实现了对 MeSH 术语和基因产物的语义相似性的度量，以帮助在知识挖掘中使用 MeSH 词汇。还使用 MeSH 注释提供了从基因列表、表达谱和基因组区域中提取生物学意义的富集分析。Meshes 支持 70 多种物种，并提供高质量的可视化方法，帮助解释分析结果。
可用性和实现
meshes 是根据艺术创作 2.0 许可证发布的。源代码和文档可通过 Bioconductor（https://www.bioconductor.org/packages/meshes）免费获得。
补充信息
补充数据可在 Bioinformatics 在线获得。
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