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遗传基础的Nellore 特征：一个基因优先级和功能分析的全基因组关联研究结果。

Genetic Foundations of Nellore Traits: A Gene Prioritization and Functional Analyses of Genome-Wide Association Study Results.

机构信息

Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Genes (Basel). 2024 Aug 27;15(9):1131. doi: 10.3390/genes15091131.

DOI:10.3390/genes15091131
PMID:39336722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11431486/
Abstract

The main goal of this study was to pinpoint functional candidate genes associated with multiple economically important traits in Nellore cattle. After quality control, 1830 genomic regions sourced from 52 scientific peer-reviewed publications were used in this study. From these, a total of 8569 positional candidate genes were annotated for reproduction, 11,195 for carcass, 5239 for growth, and 3483 for morphological traits, and used in an over-representation analysis. The significant genes (adjusted -values < 0.05) identified in the over-representation analysis underwent prioritization analyses, and enrichment analysis of the prioritized over-represented candidate genes was performed. The prioritized candidate genes were , , , , , and for reproduction; , , , , , , , , , and for the carcass; and for growth traits; and no genes were prioritized for morphological traits. The functional analysis pinpointed the following genes: (plays a crucial role in spindle organization, which is essential in forming a robust mitotic centrosome), (involved in muscle cell differentiation), and (involved in protein deubiquitination, thereby improving growth). The enrichment of the functional candidate genes identified in this study highlights that these genes play an important role in the expression of reproduction, carcass, and growth traits in Nellore cattle.

摘要

本研究的主要目的是确定与Nellore 牛多个经济重要性状相关的功能候选基因。经过质量控制，本研究使用了 52 篇经过同行评审的科学出版物中的 1830 个基因组区域。从这些区域中，总共注释了 8569 个与繁殖相关的定位候选基因、11195 个与胴体相关的候选基因、5239 个与生长相关的候选基因和 3483 个与形态相关的候选基因，并进行了过表达分析。过表达分析中确定的显著基因（调整后的 - 值<0.05）进行了优先级分析，并对优先过表达候选基因进行了富集分析。优先候选基因包括与繁殖相关的、、、、、和；与胴体相关的、、、、、、、、和；与生长性状相关的和；没有基因被优先用于形态性状。功能分析确定了以下基因：（在纺锤体组织的形成中起着至关重要的作用，纺锤体组织对于形成强大的有丝分裂中心体至关重要）、（参与肌肉细胞分化）和（参与蛋白质去泛素化，从而改善生长）。本研究中确定的功能候选基因的富集表明，这些基因在 Nellore 牛的繁殖、胴体和生长性状的表达中起着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/1433027b380c/genes-15-01131-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/5ac93b6fb33f/genes-15-01131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/7cfd26a4814e/genes-15-01131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/dce002ef0f9f/genes-15-01131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/5841c335011b/genes-15-01131-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/175410dbc71a/genes-15-01131-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/8edd97f772d0/genes-15-01131-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/1433027b380c/genes-15-01131-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/5ac93b6fb33f/genes-15-01131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/7cfd26a4814e/genes-15-01131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/dce002ef0f9f/genes-15-01131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/5841c335011b/genes-15-01131-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/175410dbc71a/genes-15-01131-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/8edd97f772d0/genes-15-01131-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61aa/11431486/1433027b380c/genes-15-01131-g007.jpg

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