Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Clin Transplant. 2018 Jul;32(7):e13291. doi: 10.1111/ctr.13291. Epub 2018 Jun 15.
Racial disparities in living donor kidney transplantation (LDKT) persist but the most effective target to eliminate these disparities remains unknown. One potential target could be delays during completion of the live donor evaluation process. We studied racial differences in progression through the evaluation process for 247 African American (AA) and 664 non-AA living donor candidates at our center between January 2011 and March 2015. AA candidates were more likely to be obese (38% vs 22%: P < .001), biologically related (66% vs 44%: P < .001), and live ≤50 miles from the center (64% vs 37%: P < .001) than non-AAs. Even after adjusting for these differences, AAs were less likely to progress from referral to donation (aHR for AA vs non-AA: 0.47 P = .01). We then assessed racial differences in completion of each step of the evaluation process and found disparities in progression from medical screening to in-person evaluation (aHR: 0.62 P = .02) and from clearance to donation (aHR: 0.51 P = .02), compared with from referral to medical screening (aHR: 1.02 P = .95) and from in-person evaluation to clearance (aHR: 0.93 P = .54). Delays may be a manifestation of the transplant candidate's social network, thus, targeted efforts to optimize networks for identification of donor candidates may help address LDKT disparities.
在活体供肾移植(LDKT)中,仍然存在种族差异,但消除这些差异的最有效目标仍不清楚。一个潜在的目标可能是在活体供者评估过程完成期间的延迟。我们研究了我们中心在 2011 年 1 月至 2015 年 3 月期间 247 名非裔美国(AA)和 664 名非 AA 活体供者候选人在评估过程中的进展情况。AA 候选人更有可能肥胖(38%比 22%:P<.001)、生物学相关(66%比 44%:P<.001)、距离中心≤50 英里(64%比 37%:P<.001),而非 AA 候选人。即使在调整了这些差异后,AA 从转介到捐赠的可能性也较小(AA 与非 AA 的 aHR:0.47,P=.01)。然后,我们评估了评估过程中每一步的种族差异,发现从医疗筛查到面对面评估(aHR:0.62,P=.02)和从清除到捐赠(aHR:0.51,P=.02)的进展方面存在差异,与从转介到医疗筛查(aHR:1.02,P=.95)和从面对面评估到清除(aHR:0.93,P=.54)相比。延迟可能是移植候选者社交网络的表现,因此,有针对性地努力优化网络以确定供者候选人可能有助于解决 LDKT 差异。