Suppr超能文献

种族差异对完成活体肾捐献者评估过程的影响。

Racial differences in completion of the living kidney donor evaluation process.

机构信息

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA.

出版信息

Clin Transplant. 2018 Jul;32(7):e13291. doi: 10.1111/ctr.13291. Epub 2018 Jun 15.

Abstract

Racial disparities in living donor kidney transplantation (LDKT) persist but the most effective target to eliminate these disparities remains unknown. One potential target could be delays during completion of the live donor evaluation process. We studied racial differences in progression through the evaluation process for 247 African American (AA) and 664 non-AA living donor candidates at our center between January 2011 and March 2015. AA candidates were more likely to be obese (38% vs 22%: P < .001), biologically related (66% vs 44%: P < .001), and live ≤50 miles from the center (64% vs 37%: P < .001) than non-AAs. Even after adjusting for these differences, AAs were less likely to progress from referral to donation (aHR for AA vs non-AA: 0.47 P = .01). We then assessed racial differences in completion of each step of the evaluation process and found disparities in progression from medical screening to in-person evaluation (aHR: 0.62 P = .02) and from clearance to donation (aHR: 0.51 P = .02), compared with from referral to medical screening (aHR: 1.02 P = .95) and from in-person evaluation to clearance (aHR: 0.93 P = .54). Delays may be a manifestation of the transplant candidate's social network, thus, targeted efforts to optimize networks for identification of donor candidates may help address LDKT disparities.

摘要

在活体供肾移植(LDKT)中,仍然存在种族差异,但消除这些差异的最有效目标仍不清楚。一个潜在的目标可能是在活体供者评估过程完成期间的延迟。我们研究了我们中心在 2011 年 1 月至 2015 年 3 月期间 247 名非裔美国(AA)和 664 名非 AA 活体供者候选人在评估过程中的进展情况。AA 候选人更有可能肥胖(38%比 22%:P<.001)、生物学相关(66%比 44%:P<.001)、距离中心≤50 英里(64%比 37%:P<.001),而非 AA 候选人。即使在调整了这些差异后,AA 从转介到捐赠的可能性也较小(AA 与非 AA 的 aHR:0.47,P=.01)。然后,我们评估了评估过程中每一步的种族差异,发现从医疗筛查到面对面评估(aHR:0.62,P=.02)和从清除到捐赠(aHR:0.51,P=.02)的进展方面存在差异,与从转介到医疗筛查(aHR:1.02,P=.95)和从面对面评估到清除(aHR:0.93,P=.54)相比。延迟可能是移植候选者社交网络的表现,因此,有针对性地努力优化网络以确定供者候选人可能有助于解决 LDKT 差异。

相似文献

1
Racial differences in completion of the living kidney donor evaluation process.
Clin Transplant. 2018 Jul;32(7):e13291. doi: 10.1111/ctr.13291. Epub 2018 Jun 15.
2
Center-level factors and racial disparities in living donor kidney transplantation.
Am J Kidney Dis. 2012 Jun;59(6):849-57. doi: 10.1053/j.ajkd.2011.12.021. Epub 2012 Feb 25.
4
5
Transition from donor candidates to live kidney donors: the impact of race and undiagnosed medical disease states.
Clin Transplant. 2011 Jan-Feb;25(1):136-45. doi: 10.1111/j.1399-0012.2009.01188.x.
6
Self-advocacy is associated with lower likelihood of living donor kidney transplantation.
Am J Surg. 2021 Jul;222(1):36-41. doi: 10.1016/j.amjsurg.2020.12.035. Epub 2020 Dec 24.
7
Neighborhood Segregation and Access to Live Donor Kidney Transplantation.
JAMA Intern Med. 2024 Apr 1;184(4):402-413. doi: 10.1001/jamainternmed.2023.8184.
8
Modifiable patient characteristics and racial disparities in evaluation completion and living donor transplant.
Clin J Am Soc Nephrol. 2013 Jun;8(6):995-1002. doi: 10.2215/CJN.08880812. Epub 2013 Mar 21.
9
Of kin and kidneys: do kinship networks contribute to racial disparities in living donor kidney transplantation?
Soc Sci Med. 2014 Mar;104:42-7. doi: 10.1016/j.socscimed.2013.11.043. Epub 2013 Dec 7.
10
Health outcomes among non-Caucasian living kidney donors: knowns and unknowns.
Transpl Int. 2013 Sep;26(9):853-64. doi: 10.1111/tri.12088. Epub 2013 Mar 27.

引用本文的文献

2
Living Donor Candidates' Self-reported Health and Health Perceptions and Completion of Donor Evaluation: A Cohort Study.
Kidney Med. 2024 Oct 4;6(11):100909. doi: 10.1016/j.xkme.2024.100909. eCollection 2024 Nov.
3
Donor Perceptions and Preferences of Telemedicine and In-Person Visits for Living Kidney Donor Evaluation.
Kidney Int Rep. 2024 May 15;9(8):2453-2461. doi: 10.1016/j.ekir.2024.05.009. eCollection 2024 Aug.
4
Progress made toward equitable transplantation in children and young adults with kidney disease.
Pediatr Nephrol. 2024 Sep;39(9):2593-2600. doi: 10.1007/s00467-024-06309-5. Epub 2024 Feb 12.
5
Relationships, race/ethnicity, gender, age, and living kidney donation evaluation willingness.
Transpl Immunol. 2024 Apr;83:101980. doi: 10.1016/j.trim.2023.101980. Epub 2024 Jan 4.
6
Racial Equity in Living Donor Kidney Transplant Centers, 2008-2018.
JAMA Netw Open. 2023 Dec 1;6(12):e2347826. doi: 10.1001/jamanetworkopen.2023.47826.
7
The Determinants and Consequences of Living Donor Discussion Direction.
Prog Transplant. 2023 Dec;33(4):310-317. doi: 10.1177/15269248231212913. Epub 2023 Nov 9.
8
African American/Black race, apolipoprotein L1 , and serum creatinine among persons with HIV.
AIDS. 2023 Dec 1;37(15):2349-2357. doi: 10.1097/QAD.0000000000003708. Epub 2023 Aug 30.
9
Expanding Access to Living Donor Kidney Transplants Through Social Networks.
Kidney Med. 2023 May 6;5(6):100654. doi: 10.1016/j.xkme.2023.100654. eCollection 2023 Jun.
10
Dialysis Patients' Social Networks and Living Donation Offers.
Kidney Med. 2023 Apr 15;5(6):100640. doi: 10.1016/j.xkme.2023.100640. eCollection 2023 Jun.

本文引用的文献

1
KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.
Transplantation. 2017 Aug;101(8S Suppl 1):S1-S109. doi: 10.1097/TP.0000000000001769.
3
Characteristics and Evaluation of Geographically Distant vs Geographically Nearby Living Kidney Donors.
Transplant Proc. 2016 Jul-Aug;48(6):1934-9. doi: 10.1016/j.transproceed.2016.03.042.
4
A Smartphone App for Increasing Live Organ Donation.
Am J Transplant. 2016 Dec;16(12):3548-3553. doi: 10.1111/ajt.13961. Epub 2016 Aug 10.
6
Financial Neutrality for Living Organ Donors: Reasoning, Rationale, Definitions, and Implementation Strategies.
Am J Transplant. 2016 Jul;16(7):1973-81. doi: 10.1111/ajt.13813. Epub 2016 May 9.
8
Living Donor Kidney Transplantation: Overcoming Disparities in Live Kidney Donation in the US--Recommendations from a Consensus Conference.
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1687-95. doi: 10.2215/CJN.00700115. Epub 2015 Apr 16.
9
Living donor transplant education for African American patients with end-stage renal disease.
Prog Transplant. 2014 Dec;24(4):362-70. doi: 10.7182/pit2014830.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验