Division of Hematology, Faculty of Health Sciences, Assuta Ashdod University Hospital, Ben Gurion University of the Negev, Beersheba, Israel.
Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Tel Hashomer, Israel.
Oral Dis. 2018 Oct;24(7):1343-1348. doi: 10.1111/odi.12901. Epub 2018 Jul 5.
Up to 30% of multiple myeloma (MM) patients have subclinical amyloid deposits. These patients are under-recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The objective of this study was to assess the prevalence and characteristics at presentation of oral amyloidosis in a large cohort of MM patients.
The prevalence and characteristics of oral amyloidosis in a large cohort of MM patients who were referred for oral evaluation before and during bisphosphonate therapy were assessed, retrospectively.
Among 212 patients analysed, 13 (6%) were diagnosed with concomitant light chain (AL) amyloidosis. In 54% (n = 7), lesions in the oral cavity compatible with amyloid deposition were detected by examination.
The salient feature of this study is the high prevalence of oral manifestations among MM patients with amyloidosis. These results highlight the value of routine oral cavity examination and biopsy as a safe and simple method for detecting light chain amyloidosis.
多达 30%的多发性骨髓瘤（MM）患者存在亚临床淀粉样沉积物。这些患者认识不足，更容易发生药物毒性、出血和死亡。早期诊断和调整治疗至关重要。口腔黏膜活检可能是一种潜在有用的诊断工具。本研究的目的是评估在接受双膦酸盐治疗前后进行口腔评估的大量 MM 患者中，口腔淀粉样变性的患病率和特征。
回顾性评估了 212 例患者中同时存在轻链（AL）淀粉样变性的患病率和特征。在 54%（n=7）的患者中，通过检查发现口腔内有与淀粉样沉积相符的病变。
本研究的突出特点是淀粉样变性 MM 患者口腔表现的高患病率。这些结果强调了常规口腔检查和活检作为一种安全、简单的方法来检测轻链淀粉样变性的价值。
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