系统性轻链淀粉样变性中的喉气管受累
Laryngotracheal Involvement in Systemic Light Chain Amyloidosis.
作者信息
Ginat Daniel T, Schulte Jefree, Portugal Louis, Cipriani Nicole A
机构信息
Department of Radiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Department of Pathology, University of Chicago, Chicago, IL, USA.
出版信息
Head Neck Pathol. 2018 Mar;12(1):127-130. doi: 10.1007/s12105-017-0831-0. Epub 2017 Jun 14.
Abstract
Laryngotracheal amyloid deposition is an uncommon manifestation of systemic light chain amyloidosis. Diagnostic imaging, such as CT, is useful for suggesting the possibility of amyloidosis and delineating the extent of the lesions for surgical management; however, the diagnosis is confirmed with the histologic finding of amorphous eosinophilic material which stains positively for Congo red and may show apple green birefringence on polarization. These features are exemplified in this sine qua non radiology-pathology correlation article.
摘要
喉气管淀粉样变沉积是系统性轻链淀粉样变性的一种罕见表现。诊断性影像学检查，如CT，有助于提示淀粉样变性的可能性并描绘病变范围以指导手术治疗；然而，诊断需通过刚果红染色呈阳性且在偏振光下可能显示苹果绿双折射的无定形嗜酸性物质的组织学发现来确诊。这些特征在这篇必不可少的放射学与病理学相关性文章中得到了例证。
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本文引用的文献
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Annu Rev Pathol. 2017 Jan 24;12:277-304. doi: 10.1146/annurev-pathol-052016-100200. Epub 2016 Dec 5.
2
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3
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Br J Haematol. 2016 Jan;172(2):170-86. doi: 10.1111/bjh.13805. Epub 2015 Oct 22.
4
Al amyloidosis.淀粉样变。
Orphanet J Rare Dis. 2012 Aug 21;7:54. doi: 10.1186/1750-1172-7-54.
5
Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases.头颈部淀粉样变性：14 例临床病理特征及免疫组化分析。
J Oral Pathol Med. 2012 Feb;41(2):178-85. doi: 10.1111/j.1600-0714.2011.01073.x. Epub 2011 Aug 29.
6
The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse.因发声滥用导致的声带良性肿块病变的临床病理谱。
Int J Surg Pathol. 2011 Oct;19(5):583-7. doi: 10.1177/1066896911411480. Epub 2011 Jun 16.
7
Imaging of focal amyloid depositions in the head, neck, and spine: amyloidoma.头部、颈部和脊柱局灶性淀粉样沉积的影像学表现：淀粉样瘤。
AJNR Am J Neuroradiol. 2010 Aug;31(7):1165-70. doi: 10.3174/ajnr.A1977. Epub 2010 Jan 14.
8
Severe diffuse systemic amyloidosis with involvement of the pharynx, larynx, and trachea: CT and MR findings.累及咽、喉和气管的严重弥漫性系统性淀粉样变性：CT和MR表现
AJNR Am J Neuroradiol. 2007 Sep;28(8):1557-8. doi: 10.3174/ajnr.A0604.
9
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10
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Arch Pathol Lab Med. 2005 Feb;129(2):215-8. doi: 10.5858/2005-129-215-PLLARO.
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