Department of Chemistry , Nanchang University , 999 Xuefu Avenue , Nanchang 330031 , China.
Department of Chemistry and the Tsinghua Center for Frontier Polymer Research , Tsinghua University , Beijing 100084 , P.R. China.
Biomacromolecules. 2018 Jun 11;19(6):1858-1868. doi: 10.1021/acs.biomac.8b00437. Epub 2018 May 23.
Melanins are well-known biopolymers that are ubiquitous in nature, distributed widely in microorganisms, plants, and animals, and play significant physiological roles. They are mostly biopolymers formed from phenolic compounds by polymerization via quinones. Poly(dopamine) (PDA), a melanin-like material, is similar in structure and properties to eumelanin and has attracted considerable interest for various types of biological applications. This review outlines the recent advances in the structure and synthesis of PDA and discusses applications of PDA in many biological fields, such as biological imaging, photothermal therapy, and drug delivery systems. The purpose of this review is to give a brief overview of the synthesized procedures, structure, biomedical applications, and prospects of melanin-like materials.
黑色素是一种众所周知的生物聚合物,在自然界中无处不在,广泛分布于微生物、植物和动物中,并发挥着重要的生理作用。它们主要是由酚类化合物通过聚合形成醌而形成的生物聚合物。聚多巴胺(PDA)是一种类似黑色素的物质,在结构和性质上与真黑色素相似,因此在各种类型的生物应用中引起了广泛关注。本文概述了 PDA 的结构和合成方面的最新进展,并讨论了 PDA 在许多生物领域的应用,如生物成像、光热治疗和药物输送系统。本文的目的是简要概述类似黑色素材料的合成过程、结构、生物医学应用和前景。